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Home Antibody All anti-TNFRSF12A antibodies

Anti-TNFRSF12A Antibody

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Specifications Citations (0) Related Products Product Documents
SKU Description Amount Price Availability*  
TA306358 Rabbit Polyclonal Fn14 Antibody 100ug $325 3-7 Days
LC402582 TNFRSF12A HEK293T cell transient overexpression lysate (as WB positive control) 20ug $50 In Stock
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WB(1)
IHC(1)
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Also for TNFRSF12A (NM_016639)
cDNA Clone shRNA/siRNA CRISPR KO Kit Protein Antibody

OriGene Data

ImmunogenFn14 antibody was raised against a human IgG1 Fc-tagged Fn14 protein.
Clone Name IsotypeIgG
Species ReactivityHuman Concentration1ug/ul
Guaranteed Application *WB, IHC Suggested DilutionsWB: 1 ug/ml
BufferPBS containing 0.02% sodium azide.
Purification Affinity chromatography purified via peptide column

Reference Data

Target NameHomo sapiens tumor necrosis factor receptor superfamily, member 12A (TNFRSF12A)
Alternative NameCD266; FN14; TWEAKR
Database LinkNP_057723
Entrez Gene 51330 Human
FunctionTWEAK is a TNF family member produced by IFN-gamma-stimulated monocytes and induces multiple cell death pathways including caspase-dependent apoptosis and cathepsin B-dependent necrosis. These pathways are mediated by the binding of TWEAK by fibroblast growth factor 14 (Fn14), a member of the TNF receptor superfamily. Yeast two-hybrid experiments have shown that FN14 will bind to the TNFR-associated factors TRAF1, TRAF2, TRAF3, and TRAF5, suggesting that the signaling pathway induced by TWEAK may be mediated by one or more of these adaptor molecules. Fn14 is induced during liver regeneration and is highly expressed in hepatocellular carcinomas. In addition, TWEAK induces liver progenitor cell proliferation, suggesting Fn14 may play a role in hepatocyte growth control and liver neoplasia.
Related PathwayTransmembraneDruggable Genome Cytokine-cytokine receptor interaction

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

Western blot analysis of Fn14 in (A) mock- and (B) Fn14-GPI-transfected 293 cells with Fn14 antibody at 1 ug/ml.
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Immunohistochemistry of Fn14 in human liver tissue with Fn14 antibody at 2.5 ug/ml.
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