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Home Antibody All anti-ATM antibodies

Anti-ATM Antibody

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SKU Description Amount Price Availability*  
TA306355 Rabbit Polyclonal ATM Antibody 100ug $325 3-7 Days
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WB(1)
IHC(1)

OriGene Data

ImmunogenATM antibody was raised against a peptide corresponding to 14 amino acids near the carboxy terminus of human ATM.
Clone Name IsotypeIgG
Species ReactivityHuman Concentration1ug/ul
Guaranteed Application *WB, IHC Suggested DilutionsWB: 1 - 2 ug/ml
BufferPBS containing 0.02% sodium azide.
Purification Affinity chromatography purified via peptide column

Reference Data

Target NameHomo sapiens ATM serine/threonine kinase (ATM)
Alternative NameAT1; ATA; ATC; ATD; ATDC; ATE; TEL1; TELO1
Database LinkNP_000042
Entrez Gene 472 Human
FunctionDNA double strand breaks represent a major threat to an organism’s genome. Eukaryotic cells have developed mechanisms that sense the presence this damage and initiate suitable responses that can include DNA repair, cell cycle delay, and programmed cell death. The ATM (mutated in Ataxia-Telangiectasia) protein kinase is activated following the formation of DNA double strand breaks, phosphorylating p53 and another kinase CHK2. This initiates a signaling cascade leading to the phosphorylation and inhibition of Cdc25, ultimately preventing cell cycle progression. In some cell types, such as the hemapoietic system, this leads to apoptosis instead of cell cycle arrest. Multiple isoforms of ATM are known to exist.
Related PathwayProtein KinaseTranscription FactorsDruggable Genome Cell cyclep53 signaling pathwayApoptosis

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

Western blot analysis of ATM in Daudi whole cell lysate with ATM antibody at (A) 1 and (B) 2 ug/ml.
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Immunohistochemistry of ATM in human lymph node tissue with ATM antibody at 2.5 ug/ml.
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