Home Antibody All anti-TANK antibodies
Also for TANK (NM_004180)
|TANK antibody was raised against a 14 amino acid peptide from near the carboxy terminus of human TANK.|
|Human, Mouse, Rat
||WB: 1 - 2 ug/ml
|PBS containing 0.02% sodium azide.|
|Affinity chromatography purified via peptide column (Protein A or G Sepharose)
|Homo sapiens TRAF family member-associated NFKB activator (TANK), transcript variant 1|
|I-TRAF; ITRAF; TRAF2|
|TANK was initially identified as a novel TRAF-interacting protein that regulated TRAF-mediated signal transduction. Specifically, ligand binding by surface receptors in the tumor necrosis factor (TNF) receptor and Toll/interleukin-1 (IL-1) receptor families lead to the formation of a TRAF/TANK complex that mediates the activation of the transcription factor NF-kappaB. This activation of NF-kappaB occurs through an association with the kinases IKKepsilon and TBK1. More recently, it was shown that these proteins can then form a complex with NEMO, a protein that regulates the activity of the IkappaB complex. This suggests that in addition to the possibility that TBK1 and IKKepsilon activate the IKKs, the association with the IKK complex may help these kinases modulate other functions, such as the transactivation potential of NF-kappaB proteins. At least two isoforms of TANK are known to exist.|
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Western blot analysis of TANK in Daudi cell lysate with TANK antibody at (A) 0.5, (B) 1 and (C) 2 ug/ml.
Immunohistochemistry of TANK in rat spleen tissue with TANK antibody at 10 ug/ml.