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Home Antibody All anti-UNG antibodies

Anti-UNG Antibody

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Specifications Citations (0) Related Products Product Documents
SKU Description Amount Price Availability*  
TA306336
  • Rabbit Polyclonal UNG1 Antibody
  • Free Sample of Positive Control: HEK293T cell transient overexpression lysate (LC418736) , 20ug Explanation
100ug $325 3-7 Days

Buy any antibody of 100ul or more, get a free package of 3 loading control antibody samples. View Details Add to Shopping Cart

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WB(1)
IHC(1)

OriGene Data

ImmunogenUNG1 antibody was raised against a 13 amino acid peptide from near the amino terminus of human UNG1.
Clone Name IsotypeIgG
Species ReactivityHuman, Mouse, Rat Concentration1ug/ul
Guaranteed Application *WB, IHC Suggested DilutionsWB: 1 - 2 ug/ml
BufferPBS containing 0.02% sodium azide.
Purification Affinity chromatography purified via peptide column

Reference Data

Target NameHomo sapiens uracil-DNA glycosylase (UNG), transcript variant 1
Alternative NameDGU; HIGM4; HIGM5; UDG; UNG1; UNG15; UNG2
Database LinkNP_003353
Entrez Gene 7374 Human
Entrez Gene 22256 Mouse
Entrez Gene 304577 Rat
FunctionThe human uracil-DNA glycosylase (UNG) gene encodes both mitochondrial (UNG1) and nuclear (UNG2) forms through differentially regulated promotes and alternative splicing. While UNG2 is the major enzyme in the base excision repair pathway that removes uracil residues from nuclear DNA that arise through either misincorporation during replication or cytosine deamination, inhibition of UNG1 by uracil glycosylase inhibitor did not lead to increased levels of spontaneous or induced mitochondrial DNA mutations. However, decreased levels of UNG activity and increased oxidative damage to mitochondrial DNA were seen in older mice, suggesting that mitochondrial DNA repair mechanisms may be involved in various neurodegenerative disorders in an age-dependent manner. This UNG1 antibody will not cross-react with UNG2.
Related PathwayStem cell - PluripotencyDruggable Genome Base excision repairPrimary immunodeficiency

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

Western blot analysis of UNG1 in C2C12 cell lysate with UNG1 antibody at (A) 0.5, (B) 1 and (C) 2 ug/ml.
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Immunohistochemistry of UNG1 in human heart tissue with UNG1 antibody at 2 ug/ml.
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