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Also for CD5L (NM_005894)
|AIM antibody was raised against a 16 amino acid peptide near the amino terminus of human AIM.|
||WB: 1 - 2 ug/ml
|PBS containing 0.02% sodium azide.|
|Affinity chromatography purified via peptide column (Protein A or G Sepharose)
|Homo sapiens CD5 molecule-like (CD5L)|
|AIM; API6; PRO229; SP-ALPHA; Spalpha|
|Apoptosis inhibitor of macrophages (AIM) is a member of the scavenger receptor cysteine-rich domain superfamily (SRCR-SF) initially identified as an inducible cell surface ligand of CD5. It was shown that AIM functions in the thymus as the inducer of resistance to apoptosis within CD4+/CD8+ thymocytes and as the supporter of the viability of these cells before thymic selection. AIM was also shown to support macrophage survival and enhance their phagocytic function. More recent experiments using recombinant AIM significantly inhibited apoptosis of NKT and T cells obtained from C. parvum-stimulated livers in vitro, suggesting that AIM functions to induce resistance to apoptosis in these cells and supports host defense against inflammation during infection.|
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Western blot analysis of AIM in human lymph node tissue lysate with AIM antibody at (A) 1, (B) 2 and (C) 4 ug/ml.
Immunohistochemistry of AIM in human lymph node tissue with AIM antibody at 2 ug/ml.