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Home Antibody All anti-TNFSF12 antibodies

Anti-TNFSF12 Antibody


Specifications Citations Customer Reviews Product Documents
SKU Description Amount Price Availability*  
TA306313 Rabbit Polyclonal TWEAK Antibody 100ug $325 2 Weeks
LC418410 TNFSF12 HEK293T cell transient overexpression lysate (as WB positive control) 20ug $50 In Stock
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OriGene Data

ImmunogenTWEAK antibody was raised against recombinant human TWEAK.
Clone Name IsotypeIgG
Species ReactivityHuman, Mouse, Rat ConcentrationLot dependent; please refer to CoA along with shipment
Guaranteed Application *WB, IHC Suggested DilutionsWB: 1 ug/mL, ICC: 10 ug/mL
BufferPBS containing 0.02% sodium azide.
Purification Purified IgG

Reference Data

Target NameHomo sapiens tumor necrosis factor (ligand) superfamily, member 12 (TNFSF12), transcript variant 1
Alternative NameAPO3L; DR3LG; TWEAK
Database LinkNP_003800
Entrez Gene 8742 Human
Entrez Gene 21944 Mouse
Entrez Gene 360548 Rat
FunctionTNF-related weak inducer of apoptosis (TWEAK) is a member of the tumor necrosis factor superfamily (TNFSF) of structurally related cytokines. Like most other members of this family, TWEAK is a cell surface-associated type II transmembrane protein although a smaller, biologically active form can also be generated by cleavage near the cell membrane (1,2). TWEAK has multiple biological activities, including stimulation of cell growth and angiogenesis (3), induction of inflammatory cytokines (4), in addition to stimulation of apoptosis (5). The TWEAK signal transduction pathway has not been well established but it appears to signal via TweakR/Fn14 in a manner similar to that described for other TNFSF members that bind receptors lacking death domains (1). Despite its predicted molecular weight of 27kDa, TWEAK may migrate at aberrant positions in SDS-PAGE.
Related PathwaySecreted ProteinTransmembraneDruggable Genome Cytokine-cytokine receptor interaction

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
Western blot analysis of (A) 5 ng, (B) 25 ng and (C) 50 ng of recombinant TWEAK with TWEAK antibody at 1 ug/ml.

IHC Image
Immunohistochemistry of TWEAK in human brain tissue with TWEAK antibody at 10 ug/ml.


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