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Home Antibody All anti-SOCS1 antibodies

Anti-SOCS1 Antibody

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA306303
  • Rabbit Polyclonal SOCS1 Antibody
  • FREE positive control: HEK293T cell transient overexpression lysate (LC401230) , 20ug
100ug 325 In Stock
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WB(1)
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Also for SOCS1 (NM_003745)
cDNA Clone shRNA/siRNA Lysate Protein Antibody

OriGene Data

ImmunogenSOCS1 antibody was raised against a 15 amino acid peptide from near the carboxy terminus of human SOCS1.
Clone Name IsotypeIgG
Species ReactivityHuman, Mouse, Rat ConcentrationLot Dependent
Guaranteed Application *WB Suggested DilutionsWB: 1 - 2 ug/ml
BufferPBS containing 0.02% sodium azide.
Purification Affinity chromatography purified via peptide column

Reference Data

Target NameHomo sapiens suppressor of cytokine signaling 1 (SOCS1)
Alternative NameCIS1; CISH1; JAB; SOCS-1; SSI-1; SSI1; TIP3
Database LinkNP_003736
FunctionThe Suppressor of cytokine signaling (SOCS) and cytokine-inducible SH2 proteins are a family of intracellular proteins which regulate the immune cell responses to cytokines (1). SOCS1 acts to suppress dendritic cell (DC) as well as T cell hyperactivation following cytokine signaling by inhibiting JAK tyrosine kinase, a kinase necessary for type I and II cytokine receptors to initiate signaling, by directly binding to the catalytic domain of the kinase (2). SOCS1 also possesses E3 ubiquitin protein ligase activity that results in the polyubiquitination of its target proteins and subsequent degradation by the proteosome (3). It is through this method that SOCS1 negatively regulates signaling by Toll-like receptors TLR2 and TLR4 by mediating the degradation of the TLR signaling adaptor protein TIRAP (4).
Related Pathway
Adipogenesis
EGFR1 Signaling Pathway
Jak-STAT signaling pathway

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WB Image
Western blot analysis of SOCS1 in Human spleen cell lysate with SOCS1 antibody at (A) 1, (B) 2 and (C) 4 µg/ml.

 

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