Home Antibody All anti-IL32 antibodies
Also for IL32 (NM_001012631)
|IL-32 antibody was raised against a 15 amino acid peptide from near the carboxy terminus of human IL-32.|
||WB: 5 - 10 ug/ml
|PBS containing 0.02% sodium azide.|
|Affinity chromatography purified via peptide column
|Homo sapiens interleukin 32 (IL32), transcript variant 1|
|IL-32alpha; IL-32beta; IL-32delta; IL-32gamma; NK4; TAIF; TAIFa; TAIFb; TAIFc; TAIFd|
Entrez Gene 9235 Human
|Interleukin-32 (IL-32) was initially identified as a transcript (NK4) that is selectively expressed in lymphocytes and NK cells and whose expression is increased following activation by IL-2 . It was later re-isolated from an IL-18-treated lung carcinoma cell line and re-named IL-32 (2). IL-32 is unusual in that it does not share sequence homology with known cytokine families and is highly expressed in immune tissues, existing in at least four differentially spliced isoforms. Because treatment of human monocytic and mouse macrophage cells with IL-32 induces several proinflammatory cytokines such as TNF-alpha, IL-8 and MIP-2, and because it is also induced in human peripheral lymphocyte cells after mitogen stimulation and in epithelial cells by IFNgamma, it has been suggested that IL-32 may play a role in autoimmune and inflammatory diseases such as rheumatoid arthritis (3).|
|Secreted Protein |
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Western blot analysis of IL-32 in human spleen cell lysate with IL-32 antibody at (A) 5 and (B) 10 ug/ml shows two isoforms of IL-32.
Immunohistochemistry of IL-32 in human spleen tissue with IL-32 antibody at 10 ug/ml.