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Home Antibody All anti-Il31 antibodies

Anti-Il31 Antibody

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA306295
  • Rabbit Polyclonal IL-31 Antibody
  • Free Sample of Positive Control: HEK293T cell transient overexpression lysate (LC423052) , 20ug
100ug 325 3-7 Days
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WB(1)
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Also for Il31 (NM_001014336)
cDNA Clone shRNA/siRNA Lysate Protein Antibody

OriGene Data

ImmunogenIL-31 antibody was raised against a 18 amino acid peptide from near the center of human IL-31.
Clone Name IsotypeIgG
Species ReactivityHuman, Mouse Concentration1ug/ul
Guaranteed Application *WB Suggested DilutionsWB: 2.5 - 5 ug/ml
BufferPBS containing 0.02% sodium azide.
Purification Affinity chromatography purified via peptide column

Reference Data

Target NameHomo sapiens interleukin 31 (IL31)
Alternative NameIL-31
Database LinkNP_001014358
FunctionInterleukin-31 (IL-31) is a recently discovered T-cell cytokine closely related to IL-6 type cytokines and is preferentially produced by T helper type 2 cells (1,2). IL-31 activity is mediated through the ligand-induced oligomerization of a dimeric receptor complex containing IL-31 receptor A and oncostatin M receptor (2). In response to IL-31 binding, these proteins activate the JAK/STAT and the AKT signaling pathways (3). RNA levels of IL-31 receptor A and oncostatin M receptor are induced in activated monocytes but are expressed constitutively in epithelial cells . IL-31, when overexpressed in transgenic mice, results in the development of pruritis, alopecia, and skin lesions and in humans may result in atopic dermatitis, suggesting that IL-31 may represent a novel target for antipruritic drug development (1,4).
Related Pathway

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WB Image
Western blot analysis of IL-31 in human skeletal muscle tissue lysate with IL-31 antibody at (A) 2.5, (B) 5 and (C) 10 µg/ml.

 

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