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Home Antibody All anti-Il31 antibodies

Anti-Il31 Antibody


Specifications Citations Customer Reviews Product Documents
SKU Description Amount Price Availability*  
TA306295 Rabbit Polyclonal IL-31 Antibody 100ug $325 3-7 Days
LC423052 IL31 HEK293T cell transient overexpression lysate (as WB positive control) 20ug $50 In Stock
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Also for Il31 (NM_001014336)
cDNA Clone shRNA/siRNA CRISPR KO Kit Protein Antibody

OriGene Data

ImmunogenIL-31 antibody was raised against a 18 amino acid peptide from near the center of human IL-31.
Clone Name IsotypeIgG
Species ReactivityHuman, Mouse Concentration1ug/ul
Guaranteed Application *WB, IF Suggested DilutionsWB: 2.5 - 10 ug/mL, IF: 20 ug/mL
BufferPBS containing 0.02% sodium azide.
Purification Affinity chromatography purified via peptide column

Reference Data

Target NameHomo sapiens interleukin 31 (IL31)
Alternative NameIL-31
Database LinkNP_001014358
Entrez Gene 386653 Human
Entrez Gene 76399 Mouse
FunctionInterleukin-31 (IL-31) is a recently discovered T-cell cytokine closely related to IL-6 type cytokines and is preferentially produced by T helper type 2 cells (1,2). IL-31 activity is mediated through the ligand-induced oligomerization of a dimeric receptor complex containing IL-31 receptor A and oncostatin M receptor (2). In response to IL-31 binding, these proteins activate the JAK/STAT and the AKT signaling pathways (3). RNA levels of IL-31 receptor A and oncostatin M receptor are induced in activated monocytes but are expressed constitutively in epithelial cells . IL-31, when overexpressed in transgenic mice, results in the development of pruritis, alopecia, and skin lesions and in humans may result in atopic dermatitis, suggesting that IL-31 may represent a novel target for antipruritic drug development (1,4).
Related PathwaySecreted ProteinTransmembrane

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
Western blot analysis of IL-31 in human skeletal muscle tissue lysate with IL-31 antibody at (A) 2.5, (B) 5 and (C) 10 µg/ml.

IF Image
Immunofluorescence of IL-31 in Human Skeletal Muscle cells with IL-31 antibody at 20 ug/mL.


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