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Home Antibody All anti-Il31 antibodies

Anti-Il31 Antibody


Specifications Citations Customer Reviews Product Documents
SKU Description Amount Price Availability*  
TA306294 Rabbit Polyclonal IL-31 Antibody 100ug $325 3-7 Days
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OriGene Data

ImmunogenIL-31 antibody was raised against a 16 amino acid peptide from near the amino terminus of mouse IL-31.
Clone Name IsotypeIgG
Species ReactivityMouse Concentration1ug/ul
Guaranteed Application *WB, IHC Suggested DilutionsWB: 2.5 - 10 ug/mL, ICC: 10 ug/mL
BufferPBS containing 0.02% sodium azide.
Purification Affinity chromatography purified via peptide column

Reference Data

Target NameMus musculus interleukin 31 (Il31)
Alternative Name1700013B14Rik
Database LinkNP_083870
Entrez Gene 76399 Mouse
FunctionInterleukin-31 (IL-31) is a recently discovered T-cell cytokine closely related to IL-6 type cytokines and is preferentially produced by T helper type 2 cells (1,2). IL-31 activity is mediated through the ligand-induced oligomerization of a dimeric receptor complex containing IL-31 receptor A and oncostatin M receptor (2). In response to IL-31 binding, these proteins activate the JAK/STAT and the AKT signaling pathways (3). RNA levels of IL-31 receptor A and oncostatin M receptor are induced in activated monocytes but are expressed constitutively in epithelial cells . IL-31, when overexpressed in transgenic mice, results in the development of pruritis, alopecia, and skin lesions and in humans may result in atopic dermatitis, suggesting that IL-31 may represent a novel target for antipruritic drug development (1,4).
Related Pathway

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
Western blot analysis of IL-31 in RAW264.7 cell lysate with IL-31 antibody at (A) 2.5, (B) 5 and (C) 10 ug/ml.

IHC Image
Immunohistochemistry of IL-31 in rat skeletal muscle tissue with IL-31 antibody at 10 ug/ml.


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