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Home Antibody All anti-XBP1 antibodies

Anti-XBP1 Antibody


Specifications Citations Customer Reviews Product Documents
SKU Description Amount Price Availability*  
TA306289 Rabbit Polyclonal XBP-1 Antibody 100ug $325 3-7 Days
LC425888 XBP1 HEK293T cell transient overexpression lysate (as WB positive control) 20ug $50 In Stock
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OriGene Data

ImmunogenXBP-1 antibody was raised against a 18 amino acid peptide from near the amino terminus of human XBP-1.
Clone Name IsotypeIgG
Species ReactivityHuman, Mouse Concentration1ug/ul
Guaranteed Application *WB, IF Suggested DilutionsWB: 0.5 - 2 ug/mL, ICC: 10 ug/mL
BufferPBS containing 0.02% sodium azide.
Purification Affinity chromatography purified via peptide column

Reference Data

Target NameHomo sapiens X-box binding protein 1 (XBP1), transcript variant 2
Alternative NameTREB-5; TREB5; XBP-1; XBP2
Database LinkNP_001073007
Entrez Gene 7494 Human
Entrez Gene 22433 Mouse
FunctionX box binding protein 1 (XBP-1) is a key protein in the mammalian unfolded protein response (UPR) that protects the cell against the stress of malfolded proteins in the endoplasmic reticulum (ER) . Upon sensing unfolded proteins, an ER transmembrane endonuclease and kinase termed IRE1p is activated and excises an intron from XBP-1 mRNA. The spliced XBP-1 mRNA results in a 371 amino acid protein (XBP-1s) which is then translocated to the nucleus where it binds to the regulatory elements of downstream genes. Together with other UPR transcription factors such as ATF6, XBP-1 stimulates the production of ER stress proteins including the ER resident protein chaperones glucose regulated protein (GRP) 78 and GRP94 (3,4).
Related PathwayTranscription Factors

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
Western blot analysis of XBP-1 in HepG2 cell lysate with XBP-1 antibody at (A) 0.5, (B) 1 and (C) 2 ug/mL.

IF Image
Immunocytochemistry of XBP-1 in HepG2 cells with XBP-1 antibody at 10 ug/mL.


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