Home Antibody All anti-MAP3K5 antibodies
Also for MAP3K5 (NM_005923)
|ASK1 antibody was raised against a 16 amino acid peptide from near the carboxy terminus of human ASK1.|
||ELISA, WB: 0.5 - 2 ug/ml, ICC: 2 ug/ml, IF: 20 ug/ml
|PBS containing 0.02% sodium azide.|
|Affinity chromatography purified via peptide column
|Homo sapiens mitogen-activated protein kinase kinase kinase 5 (MAP3K5)|
|ASK1; MAPKKK5; MEKK5|
Entrez Gene 4217 Human
Entrez Gene 26408 Mouse
|Mitogen-activated protein (MAP) kinase cascades are activated in response to various extracellular stimuli, including cytokines, growth factors and environmental stresses. A novel MAP kinase kinase kinase (MAPKKK) was recently identified and designated ASK1 (for apoptosis signal-regulating kinase 1) and MAPKKK5 (1-3). ASK1 activated two different subgroups of MAPKK, MKK4 and MKK6, which in turn activated c-Jun N-terminal kinase (JNK) and p38 MAP kinase, respectively. ASK1/MAPKKK5 is activated by TNFR and Fas through the interaction with members of the TRAF family and Fas-associated protein Daxx. Overexpression of ASK1 induced apoptotic cell death, and a catalytically inactive form of ASK1 inhibited TNF-Α-induced apoptosis. ASK1 is expressed in variety of tissues and cell lines.|
|Protein KinaseDruggable Genome MAPK signaling pathwayNeurotrophin signaling pathwayAmyotrophic lateral sclerosis (ALS)|
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Western blot analysis of ASK1 in SW1353 cell lysate with ASK1 antibody at (A) 0.5, (B) 1, and (C) 2 ug/mL.
Immunocytochemistry of ASK1 in A431 cells with ASK1 antibody at 2 ug/mL.