Home Antibody All anti-BECN1 antibodies
Also for BECN1 (NM_003766)
|Beclin-1 antibody was raised against a 16 amino acid peptide from near the carboxy terminus of human Beclin-1.|
||ELISA, WB: 0.5 - 2 ug/ml, ICC: 1 ug/ml, IF: 2 ug/ml
|PBS containing 0.02% sodium azide.|
|Affinity chromatography purified via peptide column (Protein A or G Sepharose)
|Homo sapiens beclin 1, autophagy related (BECN1)|
|ATG6; beclin1; VPS30|
|Autophagy, the process of bulk degradation of cellular proteins through an autophagosomic-lysosomal pathway is important for normal growth control and may be defective in tumor cells (1,2). Beclin-1, a coiled-coil Bcl-2-interacting protein homologous to the yeast autophagy gene apg6 (3,4), is a mammalian autophagy gene that can inhibit tumorigenesis and is expressed at reduced levels in human breast carcinoma, suggesting that defects in autophagy proteins may contribute to the development or progression of tumors (5). Bcl-2 can bind to Beclin-1 and inhibit Beclin-1-dependent autophagy in yeast and mammalian cells, suggesting that Bcl-2 functions as an anti-autophagy protein as well as an anti-apoptotic protein, which helps maintain autophagy at levels that are more compatible with cell survival rather than cell death (6).|
Senescence and Autophagy
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Western blot analysis of Beclin-1 in A431 cell lysate with Beclin-1 antibody at (A) 0.5, (B) 1 and (C) 2 ug/mL.
Immunocytochemistry staining of A431 cells using Beclin-1 antibody at 1 ug/mL.