Home Antibody All anti-NGFR antibodies
Also for NGFR (NM_002507)
|NGFR antibody was raised against purified recombinant human NGFR.|
||Lot dependent; please refer to CoA along with shipment
||ELISA, WB: 1 ug/ml, ICC: 10 ug/ml
|PBS containing 0.02% sodium azide.|
|Affinity chromatography purified via peptide column
|Homo sapiens nerve growth factor receptor (NGFR)|
|CD271; Gp80-LNGFR; p75(NTR); p75NTR; TNFRSF16|
Entrez Gene 4804 Human
Entrez Gene 18053 Mouse
|The tumor necrosis factor (TNF) and TNF receptor (TNFR) gene superfamilies regulate numerous biological functions including cell proliferation, differentiation, and survival through regulating the activation of the transcription factor NF-kappaB and various mitogen-activated protein kinases (reviewed in 1). Nerve growth factor receptor (NGFR) was one of the earliest characterized members of this family (2). Also known as the low-affinity receptor p75NTR, this receptor is involved in several diverse functions such as apoptosis, neurite outgrowth during development, and myelination (reviewed in 3). Its ligands include NGF, brain-derived neurotrophic factor (BDNF), NT3, and NT4 (4). NGFR can also associate with other NGF receptors such as Trk through the cytosolic and transmembrane domains and thus can function as a co-receptor that refines Trk affinity and specificity for neurotrophins (5). Finally, upon binding of various neurotrophins, NGFR associates with tumor necrosis factor receptor-6 (TRAF6), suggesting that it can potentially function as a signal transducer for NGF signals through NGFR (6).|
|TransmembraneDruggable Genome Cytokine-cytokine receptor interactionNeurotrophin signaling pathway|
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Western blot analysis of (A) 25 ng, (B) 50 ng, and (C) 100 ng of purified recombinant NGFR with NGFR antibody at 1 ug/mL.
Immunocytochemistry of NGFR in A20 cells with NGFR antibody at 10 ug/mL.