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Home Antibody All anti-TNFSF18 antibodies

Anti-TNFSF18 Antibody

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA306245
  • Rabbit Polyclonal GITRL Antibody
  • Free Sample of Positive Control: HEK293T cell transient overexpression lysate (LC401571) , 20ug Explanation
100ug 325 3-7 Days
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WB(1)
IF(1)
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Also for TNFSF18 (NM_005092)
cDNA Clone shRNA/siRNA Lysate Protein Antibody

OriGene Data

ImmunogenGITRL antibody was raised against purified recombinant human GITR ligand.
Clone Name IsotypeIgG
Species ReactivityHuman, Mouse Concentration1ug/ul
Guaranteed Application *WB, IF Suggested DilutionsELISA, WB: 1 ug/ml, ICC: 10 ug/ml
BufferPBS containing 0.02% sodium azide.
Purification Affinity chromatography purified via peptide column

Reference Data

Target NameHomo sapiens tumor necrosis factor (ligand) superfamily, member 18 (TNFSF18)
Alternative NameAITRL; GITRL; hGITRL; TL6
Database LinkNP_005083
Entrez Gene 8995 Human
Entrez Gene 240873 Mouse
FunctionThe tumor necrosis factor (TNF) and TNF receptor (TNFR) gene superfamilies regulate numerous biological functions including cell proliferation, differentiation, and survival through regulating the activation of the transcription factor NF-kappaB and various mitogen-activated protein kinases (reviewed in 1). The glucocorticoid-induced tumor necrosis factor receptor (GITR) is an emerging member of this family that is expressed on CD4+ CD25+ regulatory T cells and appears to have crucial immune regulation functions (2,3). Its ligand GITRL is expressed in endothelial and antigen-presenting cells (4) and can activate NF-kappaB, induce both pro- and anti-apoptotic effects, inhibit the suppressive activity of regulatory T cells, and co-stimulate responder T cells through GITR (5). Dominant negative forms of NIK and TRAF2 expressed in transfected 293 cells substantially inhibited NF-kappaB activation, suggesting that the GITRL-GITR pathway involves both NIK and TRAF2 (4).
Related PathwayTransmembraneDruggable Genome Cytokine-cytokine receptor interaction

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
Western blot analysis of (A) 5 ng, (B) 25 ng, and (C) 50 ng of purified recombinant GITRL with ITRL antibody at 1 ug/mL.
IF Image
Immunocytochemistry of GITRL in THP-1 cells with GITRL antibody at 10 ug/mL.

 

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