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Home Antibody All anti-EIF4EBP1 antibodies

Anti-EIF4EBP1 Antibody


Specifications Citations Customer Reviews Product Documents
SKU Description Amount Price Availability*  
TA306222 Rabbit Polyclonal 4E-BP1 Antibody 100ug $325 3-7 Days
LC401322 EIF4EBP1 HEK293T cell transient overexpression lysate (as WB positive control) 20ug $50 In Stock
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Also for EIF4EBP1 (NM_004095)
cDNA Clone shRNA/siRNA CRISPR KO Kit Protein Antibody

OriGene Data

Immunogen4E-BP1 antibody was raised against a 14 amino acid peptide from near the carboxy-terminus of human 4E-BP1.
Clone Name IsotypeIgG
Species ReactivityHuman, Mouse Concentration1ug/ul
Guaranteed Application *WB, IF Suggested DilutionsWB: 2.5 - 10 ug/mL, ICC: 2 ug/mL
BufferPBS containing 0.02% sodium azide.
Purification Affinity chromatography purified via peptide column

Reference Data

Target NameHomo sapiens eukaryotic translation initiation factor 4E binding protein 1 (EIF4EBP1)
Alternative Name4E-BP1; 4EBP1; BP-1; PHAS-I
Database LinkNP_004086
Entrez Gene 1978 Human
Entrez Gene 13685 Mouse
FunctionThe translation of mRNA in eukaryotic cells is regulated by the presence of amino acids through multiple mechanisms (reviewed in 1). One such mechanism involves the evolutionarily conserved serine/threonine kinase TOR (Target of rapamycin, also known as mTOR), which regulates cell growth and cell cycle through its ability to integrate signals from nutrient levels and growth factors (reviewed in 2). One downstream target of TOR is the eukaryotic initiation factor 4E binding protein 1 (4E-BP1) whose phosphorylation prevents its association with eIF4E, preferentially stimulating translation of mRNAs containing long, highly structured 5’-UTRs (1). Rapamycin inhibits TOR resulting in reduced cell growth and reduced rates of cell cycle and cell proliferation (reviewed in 3), at least in part by inhibiting the activity of TOR towards 4E-BP1.
Related Pathway ErbB signaling pathwaymTOR signaling pathwayInsulin signaling pathwayAcute myeloid leukemia

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
Western blot analysis of 4E-BP1 in 3T3 cell lysate with 4E-BP1 antibody at (A) 2.5, (B) 5 and (C) 10 ug/mL.

IF Image
Immunocytochemistry of 4E-BP1 in 3T3 cells with 4E-BP1 antibody at 2 ug/mL.


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