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Home Antibody All anti-TSC2 antibodies

Anti-TSC2 Antibody


Specifications Citations Customer Reviews Product Documents
SKU Description Amount Price Availability*  
TA306220 Rabbit Polyclonal TSC2 Antibody 100ug $325 3-7 Days
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OriGene Data

ImmunogenTSC2 (NT) was raised against a 14 amino acid peptide from near the amino terminus of human TSC2.
Clone Name IsotypeIgG
Species ReactivityHuman, Mouse Concentration1ug/ul
Guaranteed Application *WB, IF Suggested DilutionsWB: 2 - 4 ug/mL, ICC: 10 ug/mL, IF: 20 ug/mL
BufferPBS containing 0.02% sodium azide.
Purification Affinity chromatography purified via peptide column

Reference Data

Target NameHomo sapiens tuberous sclerosis 2 (TSC2), transcript variant 1
Alternative NameLAM; PPP1R160; TSC4
Database LinkNP_000539
Entrez Gene 7249 Human
Entrez Gene 22084 Mouse
FunctionTuberous sclerosis complex (TSC) is an autosomal dominant tumor syndrome caused by mutations in either of the TSC1 or TSC2 tumor suppressor genes. The products of these genes form a protein complex that indirectly decreases the signaling of the mammalian Target of Rapamycin (TOR), an evolutionarily conserved serine/threonine kinase that regulates cell growth and cell cycle through its ability to integrate signals from nutrient levels and growth factors (reviewed in 1,2). TOR activity is stimulated by Rheb, a member of the Ras superfamily of G-proteins, when the GTP/GDP ratio bound to Rheb is high (3). Immunoprecipitated TSC1/TSC2 has been shown to stimulate Rheb GTPase activity in vitro (4), suggesting that the TSC1/TSC2 complex decreases the ability of Rheb to stimulate TOR activity. This is supported by experiments showing that overexpression of TSC1 and TSC2 results in a significant decrease in the GTP/GDP ratio bound to Rheb and the inhibition of cell growth (4,5). At least three isoforms of TSC2 exist.
Related PathwayDruggable Genome p53 signaling pathwaymTOR signaling pathwayInsulin signaling pathway

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
Western blot analysis of TSC2 in L1210 cell lysate with TSC2 antibody at (A) 2 and (B) 4 ug/mL.

IF Image
Immunocytochemistry of TSC2 in L1210 cells with TSC2 antibody at 10 ug/mL.

IF Image
Immunofluorescence of TSC2 in L1210 cells with TSC2 antibody at 20 ug/mL.


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