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Home Antibody All anti-RHEB antibodies

Anti-RHEB Antibody

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA306215
  • Rabbit Polyclonal Rheb Antibody
  • Free Sample of Positive Control: HEK293T cell transient overexpression lysate (LC417187) , 20ug Explanation
100ug 325 3-7 Days
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WB(1)
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Also for RHEB (NM_005614)
cDNA Clone shRNA/siRNA Lysate Protein Antibody

OriGene Data

ImmunogenRabbit Rheb polyclonal antibody was raised against a 14 amino acid peptide from the amino terminus of human Rheb.
Clone Name IsotypeIgG
Species ReactivityHuman, Mouse, Rat Concentration1ug/ul
Guaranteed Application *WB Suggested DilutionsWB: 2 - 4 ug/ml
BufferPBS containing 0.02% sodium azide.
Purification Affinity chromatography purified via peptide column

Reference Data

Target NameHomo sapiens Ras homolog enriched in brain (RHEB)
Alternative NameRHEB2
Database LinkNP_005605
Entrez Gene 6009 Human
Entrez Gene 19744 Mouse
Entrez Gene 26954 Rat
FunctionRheb (Ras homolog enriched in brain) is an evolutionarily conserved member of the Ras family of small GTP-binding proteins originally found to be rapidly induced by synaptic activity in the hippocampus following seizure (1). While it is expressed at relatively high levels in the brain, Rheb is widely expressed in other tissues and may be induced by growth factor stimulation. Similar to other family members, Rheb triggers activation of the Raf-MEK-MAPK pathway (2). Biochemical and genetic studies demon-strate that Rheb has an important role in regulating the insulin/Target of rapamycin (TOR) signaling pathway (3-5). TOR is a serine/threonine protein kinase that acts as a sensor for ATP and amino acids, balancing the availability of nutrients with protein translation and cell growth. A dimeric protein complex termed TSC1/TSC2 indirectly inhibits TOR activity by inhibiting Rheb via the GAP activity of TSC2 (3).
Related Pathway mTOR signaling pathwayInsulin signaling pathway

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
Western blot analysis of Rheb in rat heart cell lysate with Rheb antibody at (A) 2 and (B) 4 µg/ml.

 

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