Home Antibody All anti-RHEB antibodies
Also for RHEB (NM_005614)
|Rabbit Rheb polyclonal antibody was raised against a 14 amino acid peptide from the amino terminus of human Rheb.|
|Human, Mouse, Rat
||WB: 2 - 4 ug/ml
|PBS containing 0.02% sodium azide.|
|Affinity chromatography purified via peptide column
|Homo sapiens Ras homolog enriched in brain (RHEB)|
Entrez Gene 6009 Human
Entrez Gene 19744 Mouse
Entrez Gene 26954 Rat
|Rheb (Ras homolog enriched in brain) is an evolutionarily conserved member of the Ras family of small GTP-binding proteins originally found to be rapidly induced by synaptic activity in the hippocampus following seizure (1). While it is expressed at relatively high levels in the brain, Rheb is widely expressed in other tissues and may be induced by growth factor stimulation. Similar to other family members, Rheb triggers activation of the Raf-MEK-MAPK pathway (2). Biochemical and genetic studies demon-strate that Rheb has an important role in regulating the insulin/Target of rapamycin (TOR) signaling pathway (3-5). TOR is a serine/threonine protein kinase that acts as a sensor for ATP and amino acids, balancing the availability of nutrients with protein translation and cell growth. A dimeric protein complex termed TSC1/TSC2 indirectly inhibits TOR activity by inhibiting Rheb via the GAP activity of TSC2 (3).|
| mTOR signaling pathwayInsulin signaling pathway|
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Western blot analysis of Rheb in rat heart cell lysate with Rheb antibody at (A) 2 and (B) 4 µg/ml.