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Home Antibody All anti-MCL1 antibodies

Anti-MCL1 Antibody

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA306207
  • Rabbit Polyclonal Mcl-1 Antibody
  • Free Sample of Positive Control: HEK293T cell transient overexpression lysate (LC411855) , 20ug Explanation
100ug 325 3-7 Days
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WB(1)
IF(1)
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Also for MCL1 (NM_021960)
cDNA Clone shRNA/siRNA Lysate Protein Antibody

OriGene Data

ImmunogenMcl-1 antibody was raised against a peptide corresponding to 16 amino acids near the carboxy-terminus of human Mcl-1.
Clone Name IsotypeIgG
Species ReactivityHuman, Mouse, Rat Concentration1ug/ul
Guaranteed Application *WB, IF Suggested DilutionsELISA, WB: 1 - 2 ug/ml, ICC: 2 ug/ml, IF: 10 ug/ml
BufferPBS containing 0.02% sodium azide.
Purification Ion exchange chromatography purified

Reference Data

Target NameHomo sapiens myeloid cell leukemia 1 (MCL1), transcript variant 1
Alternative Namebcl2-L-3; BCL2L3; EAT; Mcl-1; MCL1-ES; mcl1/EAT; MCL1L; MCL1S; TM
Database LinkNP_068779
Entrez Gene 4170 Human
Entrez Gene 17210 Mouse
Entrez Gene 60430 Rat
FunctionMyeloid cell leukimia-1 (Mcl-1) is a member of the Bcl-2 family of proteins that can act to promote cell survival (reviewed in 1). While the mechanism by which Mcl-1 inhibits apoptosis is not known, it is thought that it may heterodimerize and neutralize pro-apoptotic members of the Bcl-2 family such as Bim or Bak (2,3). Mcl-1 was originally identified in differentiating myeloid cells (4), but has since been shown to be expressed in multiple cell types. Mcl-1 is essential for embryogenesis (5) and for the development and maintenance of B and T lymphocytes in animals (3). Mcl-1 exists as at least two distinct isoforms designated Mcl-1L and Mcl-1S. In marked contrast to the larger isoform of Mcl-1, overexpression of Mcl-1S promotes cell death (6).
Related PathwayTransmembraneDruggable Genome

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
Western blot analysis of Mcl-1 in Raji cell lysates with Mcl-1 antibody at (A) 1 and (B) 2 ug/mL.
IF Image
Immunocytochemistry staining of Raji cells using Mcl-1 antibody at 2 ug/mL.

 

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