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Home Antibody All anti-CASP8 antibodies

Anti-CASP8 Antibody

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA306205
  • Rabbit Polyclonal Caspase-8 Antibody
100ug $325 In Stock
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WB(1)
IF(1)
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Also for CASP8 (NM_001080124)
cDNA Clone shRNA/siRNA Protein Request Antibody Assay

OriGene Data

ImmunogenCaspase-8 antibody was raised against a 16 amino acid peptide from near the carboxy-terminus of human Caspase-8 isoform A.
Clone Name IsotypeIgG
Species ReactivityHuman, Mouse, Rat Concentration0.5~1.0 mg/ml (Lot Dependent)
Guaranteed Application *WB, IF Suggested DilutionsELISA, WB: 0.5 - 2 ug/ml, ICC: 2 ug/ml, IF: 20 ug/ml
BufferPBS containing 0.02% sodium azide.
Purification Affinity chromatography purified via peptide column

Reference Data

Target NameHomo sapiens caspase 8, apoptosis-related cysteine peptidase (CASP8), transcript variant F
Alternative NameALPS2B; CAP4; Casp-8; FLICE; MACH; MCH5
Database LinkNP_001073593
FunctionCaspases are a family of cysteine proteases that can be divided into the apoptotic and inflammatory caspase subfamilies. Unlike the apoptotic caspases, members of the inflammatory subfamily are generally not involved in cell death but are associated with the immune response to microbial pathogens (reviewed in 1 and 2). The apoptotic subfamily can be further divided into initiator caspases, which are activated in response to death signals, and executioner caspases, which are activated by the initiator caspases and are responsible for cleavage of cellular substrates that ultimately lead to cell death (reviewed in 3). Caspase-8 is an initiator caspase that was identified as a member of the Fas/APO-1 death-inducing signaling complex (4). The adaptor molecule FADD couples procaspase-8 to the Fas receptor death domain; subsequent oligomerization promotes procaspase-8 autoactivation (reviewed in 5). FLIP, a catalytically inactive caspase-8-like molecule inhibits these interactions and thus can inhibit apoptosis (6).
Related Pathway
Apoptosis
MAPK signaling pathway
Toll-like receptor signaling pathway

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WB Image
Western blot analysis of caspase-8 in Jurkat cell lysate with caspase-8 antibody at (A) 0.5, (B) 1, and (C) 2 ug/mL.
IF Image
Immunocytochemistry of caspase-8 in Jurkat cells with caspase-8 antibody at 2 ug/mL.

 

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