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Home Antibody All anti-CASP6 antibodies

Anti-CASP6 Antibody

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA306204
  • Rabbit Polyclonal Caspase-6 Antibody
  • FREE positive control: HEK293T cell transient overexpression lysate (LC400490) , 20ug
100ug $325 3-7 Days
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WB(1)
IF(1)
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Also for CASP6 (NM_001226)
cDNA Clone shRNA/siRNA Protein/Lysate Antibody Assay

OriGene Data

ImmunogenCaspase-6 antibody was raised against a 15 amino acid peptide from near the amino-terminus of human Caspase-6.
Clone Name IsotypeIgG
Species ReactivityHuman Concentration1ug/ul
Guaranteed Application *WB, IF Suggested DilutionsELISA, WB: 0.5 - 2 ug/ml, ICC: 2 ug/ml
BufferPBS containing 0.02% sodium azide.
Purification Affinity chromatography purified via peptide column

Reference Data

Target NameHomo sapiens caspase 6, apoptosis-related cysteine peptidase (CASP6), transcript variant alpha
Alternative NameMCH2
Database LinkNP_001217
FunctionCaspases are a family of cysteine proteases that can be divided into the apoptotic and inflammatory caspase subfamilies. Unlike the apoptotic caspases, members of the inflammatory subfamily are generally not involved in cell death but are associated with the immune response to microbial pathogens (reviewed in 1 and 2). The apoptotic subfamily can be further divided into initiator caspases, which are activated in response to death signals, and executioner caspases, which are activated by the initiator caspases and are responsible for cleavage of cellular substrates that ultimately lead to cell death (reviewed in 3). Caspase-6 is an executioner caspase that was idientifed based on its homology with human caspases 2 and 3 as well as the C. elegans cell death protein CED-3 (4). It possesses two isoforms, of which only the longer form possesses protease activity (4). Caspase-6 is highly expressed in adult brain and may play a role in several neuronal pathologies (5).
Related Pathway
Apoptosis
MAPK signaling pathway

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WB Image
Western blot analysis of caspase-6 in Jurkat cell lysate with caspase-6 antibody at (A) 0.5, (B) 1, and (C) 2 ug/mL.
IF Image
Immunocytochemistry of caspase-6 in Jurkat cells with caspase-6 antibody at 2 ug/mL.

 

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