Home Antibody All anti-CASP1 antibodies
Also for CASP1 (NM_001223)
|Caspase-1 antibody was raised against a 15 amino acid peptide from near the middle of human Caspase-1.|
||Lot dependent; please refer to CoA along with shipment
||WB: 0.5 ug/ml
|PBS containing 0.02% sodium azide.|
|Affinity chromatography purified via peptide column
|Homo sapiens caspase 1, apoptosis-related cysteine peptidase (CASP1), transcript variant beta|
|ICE; IL1BC; P45|
Entrez Gene 834 Human
|Caspases are a family of cysteine proteases that can be divided into the apoptotic and inflammatory caspase subfamilies. Unlike the apoptotic caspases, members of the inflammatory subfamily are generally not involved in cell death but are associated with the immune response to microbial pathogens (reviewed in 1 and 2). Members of this subfamily include caspase-1, -4, -5, and -12 and can activate proinflammatory cytokines such as IL-1? and IL-18 (3,4). Caspase-1 was initially identified as an IL-1beta-converting enzyme (5); later experiments revealed it to be a mammalian homolog of the C. elegans cell death gene ced-3 (6) whose overexpression can induce apoptosis in fibroblasts (7).|
|ProteaseDruggable Genome NOD-like receptor signaling pathwayCytosolic DNA-sensing pathwayAmyotrophic lateral sclerosis (ALS)|
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Western blot analysis of Caspase-1 in HeLa cell lysate with Caspase-1 antibody (IN) at (A) 0.5, (B) 1, and (C) 2 ug/ml.
Immunohistochemistry of caspase-1 in human spleen tissue with caspase-1 antibody at 10 ug/ml.