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Home Antibody All anti-CASP4 antibodies

Anti-CASP4 Antibody

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SKU Description Amount Price Availability*  
TA306196
  • Rabbit Polyclonal Caspase-4 Antibody
  • Free Sample of Positive Control: HEK293T cell transient overexpression lysate (LC400489) , 20ug Explanation
100ug $325 3-7 Days

Buy any antibody of 100ul or more, get a free package of 3 loading control antibody samples. View Details Add to Shopping Cart

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WB(1)
IHC(1)
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Also for CASP4 (NM_001225)
cDNA Clone shRNA/siRNA CRISPR KO Kit Protein Antibody

OriGene Data

ImmunogenCaspase-4 antibody was raised against a 15 amino acid peptide from near the center of human Caspase-4.
Clone Name IsotypeIgG
Species ReactivityHuman Concentration1ug/ul
Guaranteed Application *WB, IHC Suggested DilutionsWB: 2 ug/ml
BufferPBS containing 0.02% sodium azide.
Purification Affinity chromatography purified via peptide column

Reference Data

Target NameHomo sapiens caspase 4, apoptosis-related cysteine peptidase (CASP4), transcript variant alpha
Alternative NameICE(rel)II; ICEREL-II; ICH-2; Mih1/TX; TX
Database LinkNP_001216
Entrez Gene 837 Human
FunctionCaspases are a family of cysteine proteases that can be divided into the apoptotic and inflammatory caspase subfamilies. Unlike the apoptotic caspases, members of the inflammatory subfamily are generally not involved in cell death but are associated with the immune response to microbial pathogens (reviewed in 1). Members of this subfamily include caspase-1, -4, -5, and -12. Activation of these caspases results in the cleavage and activation of proinflammatory cytokines such as IL-1beta and IL-18 (2,3). Caspase-4 was initially identified as a homologous protein to Caspase-1 and the C. elegans Ced-3 which could induce apoptosis in transfected cells (4). More recent studies have shown that it can be activated by ER stress and has been suggested to be involved in multiple neuronal pathologies such as Alzheimer’s disease (5).
Related PathwayProteaseDruggable Genome

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

Western blot analysis of caspase-4 in human spleen cells with caspase-4 antibody at (A) 1 and (B) 2 ug/ml.
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Immunohistochemical staining of human spleen tissue using caspase-4 antibody at 2 ug/ml.
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