Home Antibody All anti-CASP4 antibodies
Also for CASP4 (NM_001225)
|Caspase-4 antibody was raised against a 16 amino acid peptide from the amino-terminus of human Caspase-4.|
||WB: 1 ug/ml
|PBS containing 0.02% sodium azide.|
|Affinity chromatography purified via peptide column
|Homo sapiens caspase 4, apoptosis-related cysteine peptidase (CASP4), transcript variant alpha|
|ICE(rel)II; ICEREL-II; ICH-2; Mih1/TX; TX|
|Caspases are a family of cysteine proteases that can be divided into the apoptotic and inflammatory caspase subfamilies. Unlike the apoptotic caspases, members of the inflammatory subfamily are generally not involved in cell death but are associated with the immune response to microbial pathogens (reviewed in 1). Members of this subfamily include caspase-1, -4, -5, and -12. Activation of these caspases results in the cleavage and activation of proinflammatory cytokines such as IL-1beta and IL-18 (2,3). Caspase-4 was initially identified as a homologous protein to Caspase-1 and the C. elegans Ced-3 which could induce apoptosis in transfected cells (4). More recent studies have shown that it can be activated by ER stress and has been suggested to be involved in multiple neuronal pathologies such as Alzheimer’s disease (5).|
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Western blot analysis of caspase-4 in Ramos cells with caspase-4 antibody at (A) 0.5 and (B) 1 ugg/ml.
Immunohistochemical staining of mouse spleen using caspase-4 antibody at 2 ug/ml.