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Home Antibody All anti-CASP2 antibodies

Anti-CASP2 Antibody

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA306194
  • Rabbit Polyclonal Caspase-2 Antibody
100ug 325 3-7 Days
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WB(1)
IF(1)

OriGene Data

ImmunogenCaspase-2 antibody was raised against a 16 amino acid peptide from the amino-terminus of human Caspase-2.
Clone Name IsotypeIgG
Species ReactivityHuman, Mouse Concentration1ug/ul
Guaranteed Application *WB, IF Suggested DilutionsELISA, WB: 0.5 - 2 ug/ml, ICC: 2 ug/ml
BufferPBS containing 0.02% sodium azide.
Purification Affinity chromatography purified via peptide column

Reference Data

Target NameHomo sapiens caspase 2, apoptosis-related cysteine peptidase (CASP2), transcript variant 2
Alternative NameCASP-2; ICH1; NEDD-2; NEDD2; PPP1R57
Database LinkNP_001215
FunctionCaspases are a family of cysteine proteases that can be divided into the apoptotic and inflammatory caspase subfamilies. Unlike the apoptotic caspases, members of the inflammatory subfamily are generally not involved in cell death but are associated with the immune response to microbial pathogens (reviewed in 1 and 2). Members of this subfamily include caspase-1, -4, -5, and -12 and can activate proinflammatory cytokines such as IL-1beta and IL-18 (3,4). Although phylogenetically similar to this subfamily, Caspase-2 is thought to be involved in stress-induced apoptosis (5). Caspase-2 has two major isoforms; overexpression on the long form results in apoptosis while that of the short form suppresses cell death (6).
Related Pathway
Apoptosis
MAPK signaling pathway

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WB Image
Western blot analysis of caspase-2 in Ramos cells with caspase-2 antibody at (A) 0.5, (B) 1, and (C) 2 ug/mL.
IF Image
Immunocytochemistry of caspase-2 in A-20 cells with caspase-2 antibody at 2 ug/mL.

 

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