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Also for IRF3 (NM_001571)
|IRF3 antibody antibody was raised against a peptide corresponding to 14 amino acids near the center of human IRF3.|
||ELISA, WB: 1 - 4 ug/ml, ICC: 2 ug/ml, IF: 2 ug/ml
|PBS containing 0.02% sodium azide.|
|Affinity chromatography purified via peptide column
|Homo sapiens interferon regulatory factor 3 (IRF3), transcript variant 1|
|MGC94729; interferon regulatory factor 3|
|Interferons (IFN)s are involved in a multitude of immune interactions during viral infections and play a major role in both the induction and regulation of innate and adaptive antiviral mechanisms (1 for review). During infection, host-virus interactions signal downstream molecules such as transcription factors such as IFN regulatory factor-3 (IRF3) which can act to stimulate transcription of IFN-alpha/beta genes. IRF3 is present in an inactive form in the cytoplasm of most cells (2). Following viral infection, IRF3 can be activated by IkappaB kinase-epsilon and TANK-binding kinase 1 (TBK1) (3,4), whereupon IRF3 translocates to the nucleus. IRF3 can also be activated by stimulation of toll-like receptor 3 (TLR3) by dsRNA (3,5). IRF3 exists as at least two distinct isoforms.|
Toll-like receptor signaling pathway
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Western blot analysis of IRF3 in U937 whole cell lysate with IRF3 antibody at (A) 1, (B) 2, and (C) 4 ug/mL.
Immunocytochemistry of IRF3 in Ramos cells with IRF3 antibody at 2 ug/mL.