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Home Antibody All anti-BTK antibodies

Anti-BTK Antibody

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA306188
  • Rabbit Polyclonal BTK Antibody
  • Free Sample of Positive Control: HEK293T cell transient overexpression lysate (LC424947) , 20ug Explanation
100ug 325 3-7 Days
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WB(1)
IF(1)
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Also for BTK (NM_000061)
cDNA Clone shRNA/siRNA Lysate Protein Antibody

OriGene Data

ImmunogenBTK antibody was raised against a synthetic peptide corresponding to 16 amino acids near the amino-terminus of human BTK.
Clone Name IsotypeIgG
Species ReactivityHuman, Mouse Concentration1ug/ul
Guaranteed Application *WB, IF Suggested DilutionsELISA, WB: 0.5 - 2 ug/ml, ICC: 10 ug/ml, IF: 10 ug/ml
BufferPBS containing 0.02% sodium azide.
Purification Affinity chromatography purified via peptide column

Reference Data

Target NameHomo sapiens Bruton agammaglobulinemia tyrosine kinase (BTK), transcript variant 1
Alternative NameAGMX1; AT; ATK; BPK; IMD1; PSCTK1; XLA
Database LinkNP_000052
Entrez Gene 695 Human
Entrez Gene 12229 Mouse
FunctionBruton’s tyrosine kinase (BTK) was initially identified as a member of the src family for protein-tyrosine kinases that was involved in X-linked agamma-globulinaemia (1), and has since been shown to involved in a number of signaling pathways in hemapoietic lineage (reviewed in 2). It has recently been shown to interact with members of the toll-like receptor (TLR) family such as TLR4, 6, 8, and 9 (3). The TLRs are critical molecules in both the innate and adaptive immunity and can recognize diverse microbial pathogens (reviewed in 4). BTK has also been shown to interact with key proteins involved in TLR4 signal transduction such as MyD88, TIRAP, and IRAK, but not TRAF-6, suggesting that BTK is involved in lipopolysaccharide signal transduction (3).
Related PathwayProtein KinaseDruggable Genome B cell receptor signaling pathwayFc epsilon RI signaling pathwayPrimary immunodeficiency

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
Western blot analysis of BTK in U937 cell lysate with BTK antibody at (A) 0.5, (B) 1, and (C) 2 ug/mL.
IF Image
Immunocytochemistry of BTK in Daudi cells with BTK antibody at 10 ug/mL.

 

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