BTK antibody was raised against a synthetic peptide corresponding to 16 amino acids near the amino-terminus of human BTK.
Buffer
PBS containing 0.02% sodium azide.
Clone Name
Isotype
IgG
Species Reactivity
Human, Mouse
Concentration
1ug/ul
Purification
Affinity chromatography purified via peptide column
Guaranteed Application *
WB, IHC
Suggested Dilutions
BTK antibody can be used for the detection of BTK by Western blot at 0.5 to 1 µg/ml.
Background
Bruton’s tyrosine kinase (BTK) was initially identified as a member of the src family for protein-tyrosine kinases that was involved in X-linked agamma-globulinaemia (1), and has since been shown to involved in a number of signaling pathways in hemapoietic lineage (reviewed in 2). It has recently been shown to interact with members of the toll-like receptor (TLR) family such as TLR4, 6, 8, and 9 (3). The TLRs are critical molecules in both the innate and adaptive immunity and can recognize diverse microbial pathogens (reviewed in 4). BTK has also been shown to interact with key proteins involved in TLR4 signal transduction such as MyD88, TIRAP, and IRAK, but not TRAF-6, suggesting that BTK is involved in lipopolysaccharide signal transduction (3).
Related Pathway
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