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Home Antibody All anti-MAP3K7 antibodies

Anti-MAP3K7 Antibody


Specifications Citations Customer Reviews Product Documents
SKU Description Amount Price Availability*  
TA306186 Rabbit Polyclonal TAK1 Antibody 100ug $325 3-7 Days
LC418841 MAP3K7 HEK293T cell transient overexpression lysate (as WB positive control) 20ug $50 In Stock
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Also for MAP3K7 (NM_003188)
cDNA Clone shRNA/siRNA CRISPR KO Kit Protein Antibody

OriGene Data

ImmunogenTAK1 antibody was raised against a synthetic peptide corresponding to 14 amino acids near the amino-terminus of human TAK1 isoform a.
Clone Name IsotypeIgG
Species ReactivityHuman, Mouse, Rat Concentration1ug/ul
Guaranteed Application *WB, IF Suggested DilutionsWB: 1 - 4 ug/mL, IF: 20 ug/mL
BufferPBS containing 0.02% sodium azide.
Purification Affinity chromatography purified via peptide column

Reference Data

Target NameHomo sapiens mitogen-activated protein kinase kinase kinase 7 (MAP3K7), transcript variant A
Alternative NameMEKK7; TAK1; TGF1a
Database LinkNP_003179
Entrez Gene 6885 Human
Entrez Gene 26409 Mouse
Entrez Gene 313121 Rat
FunctionTAK1 (TGF-&betta; activated protein kinase 1) is a widely expressed enzyme originally identified as a mitogen-activated protein kinase kinase kinase (MAP3K7) (1). It has since been shown to mediate various intracellular signaling pathways, such as those induced by TGF-Β and members of the Toll-IL-1R (TIR) superfamily (2), thus acting as an intermediate in both proliferative and innate and adaptive immune responses (3). TAK1 is normally present in cells in a complex with TAK1-binding protein 1 (TAB1) and either TAB2 or TAB3 (4,5). Association with TAB1 triggers TAK1 kinase activity by inducing TAK1 autophosphorylation (6), while TAB2 and possibly TAB3 may contribute to SAPK2a/p38a-mediated feedback inhibition of TAK1 activity (5).
Related PathwayProtein KinaseDruggable Genome MAPK signaling pathwayWnt signaling pathwayAdherens junctionToll-like receptor signaling pathwayNOD-like receptor signaling pathwayRIG-I-like receptor signaling pathwayMore Pathways >>

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* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
Western blot analysis of TAK1 in Rat thymus cell lysate with TAK1 antibody at (A) 1, (B) 2, and (C) 4 µg/ml.

IF Image
Immunofluorescence of TAK1 in Rat Thymus cells with TAK1 antibody at 10 ug/mL.


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