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Home Antibody All anti-UBE2V1 antibodies

Anti-UBE2V1 Antibody


Specifications Citations Customer Reviews Product Documents
SKU Description Amount Price Availability*  
TA306184 Rabbit Polyclonal UEV1A Antibody 100ug $325 3-7 Days
LC422298 UBE2V1 HEK293T cell transient overexpression lysate (as WB positive control) 20ug $50 In Stock
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Also for UBE2V1 (NM_001032288)
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OriGene Data

ImmunogenUEV1A antibody was raised against a peptide corresponding to 15 amino acids near the C-terminus of human UEV1A.
Clone Name IsotypeIgG
Species ReactivityHuman, Mouse, Rat Concentration1ug/ul
Guaranteed Application *WB Suggested DilutionsWB: 1 - 4 ug/mL
BufferPBS containing 0.02% sodium azide.
Purification Ion exchange chromatography purified

Reference Data

Target NameHomo sapiens ubiquitin-conjugating enzyme E2 variant 1 (UBE2V1), transcript variant 4
Alternative NameCIR1; CROC-1; CROC1; UBE2V; UEV-1; UEV1; UEV1A
Database LinkNP_001027459
Entrez Gene 7335 Human
Entrez Gene 66589 Mouse
Entrez Gene 296390 Rat
FunctionUbiquitin-conjugating enzyme E2 (UEV1) was initially discovered as a protein similar in sequence and structure to the E2 ubiquitin-conjugating enzymes but lacking their enzymatic activity (1). There are at least two variants and multiple isoforms of UEV1. In particular, UEV1A (Ubiquitin-conjugating enzyme E2 variant 1 isoform A) has recently been shown to be an important component of the Toll-like receptor and IL-1R signaling pathway (reviewed in 2). Signals from these pathways are relayed by a number of downstream molecules such as MyD88 and tumor necrosis factor receptor associated factor (TRAF6), ultimately activating various kinases and transcription factors (2,3). UEV1A is part of a dimeric ubiquitin-conjugating enzyme complex also containing Ubc13 (ubiquitin-conjugating enzyme 13) that together with TRAF6 activates TAK1, a member of the mitogen-activated protein kinase kinase kinase family (4-6). The Ubc13-UEV1A complex also mediates the Lys-63 ubiquitination of TRAF-6, and this ubiquitination is essential for TAK1 activation (5).
Related PathwayTranscription FactorsDruggable Genome

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
Western blot analysis of UEV1A in Jurkat cell lysates with UEV1A antibody at (A) 1, (B) 2, and (C) 4 µg/ml.


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