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Home Antibody All anti-NGFRAP1 antibodies

Anti-NGFRAP1 Antibody

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA306179
  • Rabbit Polyclonal NADE Antibody
  • Free Sample of Positive Control: HEK293T cell transient overexpression lysate (LC415324) , 20ug Explanation
100ug 325 3-7 Days
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WB(1)
IHC(1)
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Also for NGFRAP1 (NM_014380)
cDNA Clone shRNA/siRNA Lysate Protein Request Antibody

OriGene Data

ImmunogenNADE antibody was raised against a peptide corresponding to 14 amino acids near the middle of human NADE.
Clone Name IsotypeIgG
Species ReactivityHuman, Mouse Concentration1ug/ul
Guaranteed Application *WB, IHC Suggested DilutionsWB: 0.5 - 2 ug/ml
BufferPBS containing 0.02% sodium azide.
Purification Ion exchange chromatography purified

Reference Data

Target NameHomo sapiens nerve growth factor receptor (TNFRSF16) associated protein 1 (NGFRAP1), transcript variant 3
Alternative NameBex; BEX3; DXS6984E; HGR74; NADE
Database LinkNP_055195
Entrez Gene 27018 Human
Entrez Gene 12070 Mouse
FunctionThe p75 neurotrophin receptor (p75NTR) is a member of the tumor necrosis receptor superfamily and can mediate cell death and cell survival in response to nerve growth factor (NGF) (1 for review). The p75NTR-associated cell death executor (NADE) mediates apoptosis by interacting with the cell death domain of p75NTR following the binding of NGF by p75NTR (2). Recent studies have shown that NADE also interacts with second mitochondria-derived activator of caspase (Smac). Co-expression of NADE and Smac promotes TRAIL-induced apoptosis and inhibits XIAP-mediated Smac ubiquitization. It has been suggested that it is this interaction between NADE and Smac that allows apoptosis to proceed (5). Finally, although initially discovered as an mRNA expressed in ovarian granulosa cells (3), NADE has been suggested to play a role in the neuronal death seen in epileptic brain damage (4).
Related PathwayDruggable Genome Neurotrophin signaling pathway

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
Western blot analysis of NADE in Human brain cell lysates with NADE antibody at 1 ug/ml in the presence (A) or absence (B) of blocking peptide.
IHC Image
Immunohistochemistry of NADE in human brain tissue with NADE antibody at 2 ug/ml.

 

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