Home Antibody All anti-NGFRAP1 antibodies
Also for NGFRAP1 (NM_014380)
|NADE antibody was raised against a peptide corresponding to 14 amino acids near the middle of human NADE.|
||WB: 0.5 - 2 ug/ml
|PBS containing 0.02% sodium azide.|
|Ion exchange chromatography purified
|Homo sapiens nerve growth factor receptor (TNFRSF16) associated protein 1 (NGFRAP1), transcript variant 3|
|Bex; BEX3; DXS6984E; HGR74; NADE|
Entrez Gene 27018 Human
Entrez Gene 12070 Mouse
|The p75 neurotrophin receptor (p75NTR) is a member of the tumor necrosis receptor superfamily and can mediate cell death and cell survival in response to nerve growth factor (NGF) (1 for review). The p75NTR-associated cell death executor (NADE) mediates apoptosis by interacting with the cell death domain of p75NTR following the binding of NGF by p75NTR (2). Recent studies have shown that NADE also interacts with second mitochondria-derived activator of caspase (Smac). Co-expression of NADE and Smac promotes TRAIL-induced apoptosis and inhibits XIAP-mediated Smac ubiquitization. It has been suggested that it is this interaction between NADE and Smac that allows apoptosis to proceed (5). Finally, although initially discovered as an mRNA expressed in ovarian granulosa cells (3), NADE has been suggested to play a role in the neuronal death seen in epileptic brain damage (4).|
|Druggable Genome Neurotrophin signaling pathway|
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Western blot analysis of NADE in Human brain cell lysates with NADE antibody at 1 ug/ml in the presence (A) or absence (B) of blocking peptide.
Immunohistochemistry of NADE in human brain tissue with NADE antibody at 2 ug/ml.