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Home All anti-NGFRAP1 antibodies
Anti-NGFRAP1 Antibody
TrueMAB™ Antibodies - Made against Authentic Protein Antigens
* Buy one primary antibody, get 50% off a GAPDH loading control antibody.
Also for NGFRAP1 (NM_014380)
OriGene Data
| NADE antibody was raised against a peptide corresponding to 14 amino acids near the middle of human NADE. |
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IgG |
| Human, Mouse |
1ug/ul |
| WB, IHC |
WB: 0.5 - 2 ug/ml |
| PBS containing 0.02% sodium azide. |
| Ion exchange chromatography purified (Protein A or G Sepharose) |
Reference Data
| Homo sapiens nerve growth factor receptor (TNFRSF16) associated protein 1 (NGFRAP1), transcript variant 3 |
| Bex; BEX3; DXS6984E; HGR74; NADE |
| NP_055195 |
| The p75 neurotrophin receptor (p75NTR) is a member of the tumor necrosis receptor superfamily and can mediate cell death and cell survival in response to nerve growth factor (NGF) (1 for review). The p75NTR-associated cell death executor (NADE) mediates apoptosis by interacting with the cell death domain of p75NTR following the binding of NGF by p75NTR (2). Recent studies have shown that NADE also interacts with second mitochondria-derived activator of caspase (Smac). Co-expression of NADE and Smac promotes TRAIL-induced apoptosis and inhibits XIAP-mediated Smac ubiquitization. It has been suggested that it is this interaction between NADE and Smac that allows apoptosis to proceed (5). Finally, although initially discovered as an mRNA expressed in ovarian granulosa cells (3), NADE has been suggested to play a role in the neuronal death seen in epileptic brain damage (4). |
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* Shipping is in business days
* OriGene provides validated application data and protocol, with money back guarantee.
WB Image
Western blot analysis of NADE in Human brain cell lysates with NADE antibody at 1 ug/ml in the presence (A) or absence (B) of blocking peptide.
IHC Image
Immunohistochemistry of NADE in human brain tissue with NADE antibody at 2 ug/ml.
Conjugation Services
OriGene provides conjugation services of TrueMAB antibodies with the following molecules:
- HRP
- Biotin
- PE
- FITC
- DyLight® 488
- DyLight® 550
- DyLight® 594
- DyLight® 633
* DyLight is a trademark of Thermo-Fisher Scientific
Bulk Order
OriGene offers bulk sizes of TrueMAB antibodies in both the BSA/glycerol formulation and the carrier-free (BSA/glycerol-free) formulation.
Contact us with your conjugation/bulk request: antibody@origene.com or 888-267-4436 (Tech Support)
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