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Home Antibody All anti-BEX3 antibodies

Anti-BEX3 Antibody


Specifications Citations Customer Reviews Product Documents
SKU Description Amount Price Availability*  
TA306179 Rabbit Polyclonal NADE Antibody 100ug $325 3-7 Days
LC415324 NGFRAP1 HEK293T cell transient overexpression lysate (as WB positive control) 20ug $50 In Stock
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OriGene Data

ImmunogenNADE antibody was raised against a peptide corresponding to 14 amino acids near the middle of human NADE.
Clone Name IsotypeIgG
Species ReactivityHuman, Mouse Concentration1ug/ul
Guaranteed Application *WB, IHC Suggested DilutionsWB: 1 ug/mL, ICC: 2 ug/mL
BufferPBS containing 0.02% sodium azide.
Purification Ion exchange chromatography purified

Reference Data

Target Namebrain expressed X-linked 3
Alternative NameBex|DXS6984E|HGR74|NADE|NGFRAP1
Database LinkNP_055195
Entrez Gene 27018 Human
Entrez Gene 12070 Mouse
FunctionThe p75 neurotrophin receptor (p75NTR) is a member of the tumor necrosis receptor superfamily and can mediate cell death and cell survival in response to nerve growth factor (NGF) (1 for review). The p75NTR-associated cell death executor (NADE) mediates apoptosis by interacting with the cell death domain of p75NTR following the binding of NGF by p75NTR (2). Recent studies have shown that NADE also interacts with second mitochondria-derived activator of caspase (Smac). Co-expression of NADE and Smac promotes TRAIL-induced apoptosis and inhibits XIAP-mediated Smac ubiquitization. It has been suggested that it is this interaction between NADE and Smac that allows apoptosis to proceed (5). Finally, although initially discovered as an mRNA expressed in ovarian granulosa cells (3), NADE has been suggested to play a role in the neuronal death seen in epileptic brain damage (4).
Related PathwayDruggable Genome Neurotrophin signaling pathway

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
Western blot analysis of NADE in Human brain cell lysates with NADE antibody at 1 ug/ml in the presence (A) or absence (B) of blocking peptide.

IHC Image
Immunohistochemistry of NADE in human brain tissue with NADE antibody at 2 ug/ml.


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