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Anti-BAD Antibody

* Buy one primary antibody, get 50% off a GAPDH loading control antibody.

WB(1)

IHC(1)

OriGene Data

Immunogen	Bad antibody was raised against a peptide corresponding to 15 amino acids near the C-terminus of human Bad.
Clone Name		Isotype	IgG
Species Reactivity	Human, Mouse, Rat	Concentration	1ug/ul
Guaranteed Application *	WB, IHC	Suggested Dilutions	WB: 0.5 - 1 ug/ml
Buffer	PBS containing 0.02% sodium azide.
Purification	Ion exchange chromatography purified (Protein A or G Sepharose)

Reference Data

Target Name	Homo sapiens BCL2-associated agonist of cell death (BAD), transcript variant 1
Alternative Name	BBC2; BCL2L8
Database Link	NP_004313
Function	Members in the Bcl-2 family are critical regulators of apoptosis by either inhibiting or promoting cell death (reviewed in 1 and 2). Bcl-2 homology 3 (BH3) domain containing pro-apoptotic proteins, such as Bax, Bid, and Bik, form a growing subclass of the Bcl-2 family. Another such protein is the Bcl-2-antagonist of cell death (Bad). Bad regulates apoptosis by forming heterodimers with anti-apoptotic proteins Bcl-2 and Bcl-xL, thereby preventing them from binding with Bax (3). Bad activity is regulated by its phosphorylation; it is inactivated by kinases such as Akt and MAP kinase and thus promotes cell survival (4), whereas JNK-induced phosphorylation promotes the apoptotic role of Bad (5).
Related Pathway	Apoptosis Focal Adhesion

Related Lysate from OriGene • Transient overexpression lysate of BCL2-associated agonist of cell death (BAD), transcript variant 1 • Transient overexpression lysate of BCL2-associated agonist of cell death (BAD), transcript variant 1 Anti-Tag Antibodies & WB Reagent • Anti-Tag Antibodies • Western Blot Reagent shRNA • BAD - Human, 4 unique 29mer shRNA constructs in retroviral RFP vector • BAD - Human, 4 unique 29mer shRNA constructs in retroviral GFP vector • Bad - Mouse, 4 unique 29mer shRNA constructs in retroviral GFP vector • BAD - Human, 4 unique 29mer shRNA constructs in retroviral untagged vector • Bad - Mouse, 4 unique 29mer shRNA constructs in retroviral untagged vector Related ORF Clones • Myc-DDK-tagged ORF clone of Homo sapiens BCL2-associated agonist of cell death (BAD), transcript variant 1 as transfection-ready DNA • Lenti ORF clone of Human BCL2-associated agonist of cell death (BAD), transcript variant 1 , Myc-DDK-tagged • GFP-tagged ORF clone of Homo sapiens BCL2-associated agonist of cell death (BAD), transcript variant 1 as transfection-ready DNA • Lenti ORF clone of Human BCL2-associated agonist of cell death (BAD), transcript variant 1, mGFP tagged Related cDNA Clones • Homo sapiens BCL2-associated agonist of cell death (BAD), transcript variant 1 as transfection-ready DNA

Conjugation Services
OriGene provides conjugation services of TrueMAB antibodies with the following molecules:

• HRP
• Biotin
• PE
• FITC
• DyLight® 488
• DyLight® 550
• DyLight® 594
• DyLight® 633

* DyLight is a trademark of Thermo-Fisher Scientific

Bulk Order
OriGene offers bulk sizes of TrueMAB antibodies in both the BSA/glycerol formulation and the carrier-free (BSA/glycerol-free) formulation.

Contact us with your conjugation/bulk request: antibody@origene.com or 888-267-4436 (Tech Support)