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Home Antibody All anti-BAD antibodies

Anti-BAD Antibody

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA306174
  • Rabbit Polyclonal BAD Antibody
  • FREE positive control: HEK293T cell transient overexpression lysate (LC429193) , 20ug
100ug 325 3-7 Days
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WB(1)
IHC(1)
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Also for BAD (NM_004322)
cDNA Clone shRNA/siRNA Lysate Protein Antibody

OriGene Data

ImmunogenBad antibody was raised against a peptide corresponding to 15 amino acids near the C-terminus of human Bad.
Clone Name IsotypeIgG
Species ReactivityHuman, Mouse, Rat Concentration1ug/ul
Guaranteed Application *WB, IHC Suggested DilutionsWB: 0.5 - 1 ug/ml
BufferPBS containing 0.02% sodium azide.
Purification Ion exchange chromatography purified

Reference Data

Target NameHomo sapiens BCL2-associated agonist of cell death (BAD), transcript variant 1
Alternative NameBBC2; BCL2L8
Database LinkNP_004313
FunctionMembers in the Bcl-2 family are critical regulators of apoptosis by either inhibiting or promoting cell death (reviewed in 1 and 2). Bcl-2 homology 3 (BH3) domain containing pro-apoptotic proteins, such as Bax, Bid, and Bik, form a growing subclass of the Bcl-2 family. Another such protein is the Bcl-2-antagonist of cell death (Bad). Bad regulates apoptosis by forming heterodimers with anti-apoptotic proteins Bcl-2 and Bcl-xL, thereby preventing them from binding with Bax (3). Bad activity is regulated by its phosphorylation; it is inactivated by kinases such as Akt and MAP kinase and thus promotes cell survival (4), whereas JNK-induced phosphorylation promotes the apoptotic role of Bad (5).
Related Pathway
Apoptosis
Focal Adhesion

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WB Image
Western blot analysis of Bad in T24 cell lysates with Bad antibody at (A) 0.5, (B) 1, and (C) 2 ug/ml.
IHC Image
Immunohistochemical staining of rat thymus using anti-Bad at 2 ug/ml.

 

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