Home Antibody All anti-TRIM5 antibodies
Also for TRIM5 (NM_033034)
|TRIM5 alpha antibody was raised against a synthetic peptide corresponding to amino acids near the mid-region of rhesus monkey TRIM5 alpha.|
||WB: 1 - 2 ug/ml
|PBS containing 0.02% sodium azide.|
|Affinity chromatography purified via peptide column
|Homo sapiens tripartite motif containing 5 (TRIM5), transcript variant alpha|
|TRIM5 is a member of a broad family of otherwise unrelated proteins defined by the presence of a tripartite motif containing a RING domain, a B-box type 1, and a B-box type 2, followed by a coiled-coil region (1). TRIM5 has six alternately spliced isoforms, the longest of which is the ? variant which also contains a carboxy-terminal B30.2 (SPRY) domain (1). Expression of TRIM5alpha variants from humans, rhesus monkeys, and African green monkeys enabled resistance to infection by various retroviruses including HIV-1 (2,3), albeit at differing efficiencies. All TRIM5alpha variants could inhibit at least two different retroviruses, but not from those viruses isolated from the same species, suggesting that TRIM5alpha acts as a natural barrier to cross-species retrovirus transmission (3)|
* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.
Western blot analysis of TRIM5 alpha expression in human stomach (A), thymus (B), and uterus (C) cell lysate with TRIM5 alpha antibody at 2 ug /ml.
Immunohistochemistry of TRIM5a in human uterus tissue with TRIM5a antibody at 2 ug/ml.