Home Antibody All anti-TRIM5 antibodies
Also for TRIM5 (NM_033034)
|TRIM5 delta antibody was raised against a synthetic peptide corresponding to 13 amino acids near the carboxy-terminus of human TRIM5 delta.|
|WB, IHC, IF
||WB: 2 ug/ml, IHC: 1 ug/ml, IF: 10 ug/ml
|PBS containing 0.02% sodium azide.|
|Affinity chromatography purified via peptide column
|Homo sapiens tripartite motif containing 5 (TRIM5), transcript variant alpha|
Entrez Gene 85363 Human
|TRIM5 is a member of a broad family of otherwise unrelated proteins defined by the presence of a tripartite motif containing a RING domain, a B-box type 1, and a B-box type 2, followed by a coiled-coil region (1). TRIM5 has five alternately spliced isoforms, the longest of which is the ? variant which also contains a carboxy-terminal B30.2 (SPRY) domain (1). Expression of TRIM5alpha variants from humans, rhesus monkeys, and African green monkeys enabled resistance to infection by various retroviruses including HIV-1 (2,3), albeit at differing efficiencies. The TRIM5delta isoform has been shown to colocalize with the topoisomerase I-interacting proteins BTBD1 and BTBD2 in punctate or elongated cytoplasmic bodies in several mouse and human cells where it appears to serve as a scaffold for the assembly of endogenous BTBD proteins. TRIM5delta also exhibits autoubiquitination activity in a RING finger- and UbcH5B-dependent manner (4).|
|Druggable Genome |
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Western blot analysis of TRIM5 delta expression in mouse brain cell lysate with TRIM5 delta antibody at 2 ug/ml.
Immunohistochemistry of TRIM5d in mouse brain tissue with TRIM5d antibody at 1 ug/ml.
Immunofluorescence of TRIM5 delta in mouse brain tissue with TRIM5 delta antibody at 10 ug/mL.