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Home Antibody All anti-XAF1 antibodies

Anti-XAF1 Antibody

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SKU Description Amount Price Availability*  
TA306145
  • Rabbit Polyclonal XAF-1 Antibody
  • Free Sample of Positive Control: HEK293T cell transient overexpression lysate (LC402596) , 20ug
100ug 325 3-7 Days
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WB(1)
IHC(1)

OriGene Data

ImmunogenXAF-1 antibody was raised against a synthetic peptide corresponding to amino acids at the C-terminus of human XAF-1.
Clone Name IsotypeIgG
Species ReactivityHuman, Mouse Concentration1ug/ul
Guaranteed Application *WB, IHC Suggested DilutionsWB: 0.5 - 2 ug/ml
BufferPBS containing 0.02% sodium azide.
Purification Affinity chromatography purified via peptide column

Reference Data

Target NameHomo sapiens XIAP associated factor 1 (XAF1), transcript variant 1
Alternative NameBIRC4BP; HSXIAPAF1; XIAPAF1
Database LinkNP_059993
FunctionXAF-1 binds to XIAP, an inhibitor of caspases-3, -7, and -9, and triggers its relocation from the cytosol to the nucleus (1,2). Overexpression of XAF-1 results in the neutralization of XIAP's ability to inhibit cell death (1). XAF-1 is normally expressed in all adult and fetal tissues but was found to be present in very low levels in a variety of cancer cell lines (3). In contrast, XIAP levels have been shown to be high in a majority of cell lines. Low XAF-1 and high basal expression of XIAP may therefore play a critical role in maintaining survival of cancer cell lines (2,3). Both IFN-alpha2 and IFN-beta can induce XAF-1 mRNA in all cells examined but induction of XAF-1 protein (as observed by immunoblot analysis) was seen only in cell lines sensitive to the apoptotic effects of IFNs (4).
Related Pathway

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WB Image
Western blot analysis of XAF-1 in human spleen lysate with XAF-1 antibody at 0.5 (lane A), 1 (lane B), and 2 (lane C) ug/ml, respectively.
IHC Image
Immunohistochemical staining of human spleen tissue using XAF-1 antibody at 2 ug/ml.

 

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