OriGene Technologies, Inc.
Search:    
Left ProductsProducts divider ServicesServices divider technologyTechnology divider researchResearch divider TechsupportTechSupport divider AboutAbout Right
 
Home Antibody All anti-CARD11 antibodies

Anti-CARD11 Antibody

div

Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA306139
  • Rabbit Polyclonal CARMA1 Antibody
  • Free Sample of Positive Control: HEK293T cell transient overexpression lysate (LC403162) , 20ug Explanation
100ug 325 In Stock
Add to Shopping Cart
WB(1)
IHC(1)
spacer
Also for CARD11 (NM_032415)
cDNA Clone shRNA/siRNA Lysate Protein Antibody

OriGene Data

ImmunogenCARMA1 antibody was raised against a synthetic peptide corresponding to amino acids at the C-terminus of human CARMA1.
Clone Name IsotypeIgG
Species ReactivityHuman, Mouse ConcentrationLot dependent; please refer to CoA along with shipment
Guaranteed Application *WB, IHC Suggested DilutionsWB: 0.5 - 2 ug/ml
BufferPBS containing 0.02% sodium azide.
Purification Affinity chromatography purified via peptide column

Reference Data

Target NameHomo sapiens caspase recruitment domain family, member 11 (CARD11)
Alternative NameBENTA; BIMP3; CARMA1; IMD11; PPBL
Database LinkNP_115791
Entrez Gene 84433 Human
Entrez Gene 108723 Mouse
FunctionCARMA proteins belong to the membrane-associated guan-ylate kinase-like (MAGUK) family of proteins that can function as molecular scaffolds that assist assembly of signal transduction molecules (1). CARMA1, CARMA2, and CARMA3 share high degrees of sequence and functional homology, but their tissue-specific distribution suggests that they serve distinct biological functions in different cell types (2-4). Both CARMA1 and CARMA3 associate with NEMO, the regulatory subunit of the I?K complex, thereby regulating activation of the NF-kappaB transcription factor (5). Also, gene inactivation studies showed a complete block in T and B cell immunity as well as an impaired response to LPS, indicating that CARMA1 is a critical regulator in both the adaptive and innate immune systems (6).
Related PathwayDruggable Genome T cell receptor signaling pathwayB cell receptor signaling pathway

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
Western blot analysis of CARMA1 expression in mouse thymus cell lysate with CARMA1 antibody at 0.5 (lane A), 1 (lane B), and 2 ug /ml (lane C), respectively.
IHC Image
Immunohistochemistry of CARMA1 in mouse thymus with CARMA1 antibody at 10 ug/ml.

 

spacer
Inc 5000 Healthcare Company Copyright © 2014 OriGene Technologies, Inc. All Rights Reserved. Legal Notices.
9620 Medical Center Dr., Suite 200, Rockville, MD 20850 • 1.888.267.4436

Reproduction of any materials from this website is strictly forbidden without permission.

All Products by: Title | Price | Category | Popularity | Best Sellers Topselling Products by: Title | Price | Category | Popularity | Favorites
Popular Categories: Popularity | Our Choices | All-Round Favorites | Title Topselling Categories: Popularity | Our Choices | All-Round Favorites | Title