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Also for TICAM1 (NM_014261)
|TRIF antibody was raised against a peptide corresponding to 14 amino acids near the C-terminus of human TRIF.|
||WB: 2 - 4 ug/ml
|PBS containing 0.02% sodium azide.|
|Ion exchange chromatography purified
|Homo sapiens toll-like receptor adaptor molecule 1 (TICAM1), transcript variant 1|
|TRIF, PRVTIRB, TICAM-1, MGC35334;MGC35334; PRVTIRB; TICAM-1; TRIF; TIR domain containing adaptor inducing interferon-beta; TIR domain-containing adaptor molecule 1; toll-like receptor adaptor molecule 1|
|TRIF is a member of the Toll/interleukin-1 receptor (TIR) family, a group of proteins that include the Toll-like receptors (TLRs) (1-3). TLRs are signaling molecules that recognize different pathogen-associated molecular patterns (PAMPs) and serve as an important link between the innate and adaptive immune responses (4). TRIF, along with other molecules such as TIRP, TIRAP, and MyD88, serves as an adaptor protein to several of the TLR molecules. Following activation of TLR3 and TLR4, TRIF engages the kinase TBK1 and allows its subsequent activation of the interferon regulatory factor (IRF)-3 (5). TRIF is also involved in the activation of TNF receptor associated factor (TRAF)-6, and ultimately the activation of NF-?B (6).|
Toll-like receptor signaling pathway
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Western blot analysis of TRIF in human lung cell lysates with TRIF antibody at (A) 2 and (B) 4 ug/ml.
Immunohistochemistry of TRIF in human lung tissue with TRIF antibody at 10 ug/ml.