Home Antibody All anti-TRAF6 antibodies
Also for TRAF6 (NM_004620)
|TRAF6 antibody was raised against a peptide corresponding to 14 amino acids near the C-terminus of human TRAF6.|
|Human, Mouse, Rat
||ELISA, WB: 1 ug/ml, ICC: 10 ug/ml, IF: 20 ug/ml
|PBS containing 0.02% sodium azide.|
|Ion exchange chromatography purified (Protein A or G Sepharose)
|Homo sapiens TNF receptor-associated factor 6, E3 ubiquitin protein ligase (TRAF6), transcript variant 2|
|Signals from the IL-1 receptor (IL-1R)/Toll-like receptor (TLR) and TNF receptor (TNFR) superfamilies are critical for regulating the function of antigen-presenting cells. Signals transduced by these molecules lead to increased expression and activation of transcription factors such as NF-?B (1,2). TNF receptor-associated factor 6 (TRAF6) is unique in that it is a signaling adapter molecule common to both families (3). TRAF6 is important in cytokine production, dendritic cell (DC) maturation, and the T cell stimulatory capacity of DCs in response to TLR and CD40 ligands (4). It can be activated in the IL-1R/TLR signaling pathway by IL-1 receptor-associated kinase 1 (IRAK-1) (5) or by other TLR adaptor molecules such as TRIF (6). Also, it has been shown that TRAF6 can interact directly with TNFR family members CD40 and RANK (7).|
MAPK signaling pathway
Toll-like receptor signaling pathway
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Western blot analysis of TRAF6 in PC-3 cell lysates with TRAF6 antibody at 1 ug/mL in the presence (A) or absence (B) of 1 ug blocking peptide.
Immunocytochemistry of TRAF6 in K562 cells with TRAF6 antibody at 0.5 ug/mL.