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Home Antibody All anti-TRAF6 antibodies

Anti-TRAF6 Antibody

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA306124
  • Rabbit Polyclonal TRAF6 Antibody
  • Free Sample of Positive Control: HEK293T cell transient overexpression lysate (LC401463) , 20ug Explanation
100ug 325 3-7 Days
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WB(1)
IF(1)
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Also for TRAF6 (NM_004620)
cDNA Clone shRNA/siRNA Lysate Protein Antibody

OriGene Data

ImmunogenTRAF6 antibody was raised against a peptide corresponding to 14 amino acids near the C-terminus of human TRAF6.
Clone Name IsotypeIgG
Species ReactivityHuman, Mouse, Rat Concentration1ug/ul
Guaranteed Application *WB, IF Suggested DilutionsELISA, WB: 1 ug/ml, ICC: 10 ug/ml, IF: 20 ug/ml
BufferPBS containing 0.02% sodium azide.
Purification Ion exchange chromatography purified

Reference Data

Target NameHomo sapiens TNF receptor-associated factor 6, E3 ubiquitin protein ligase (TRAF6), transcript variant 2
Alternative NameMGC:3310; RNF85
Database LinkNP_004611
Entrez Gene 7189 Human
Entrez Gene 22034 Mouse
Entrez Gene 311245 Rat
FunctionSignals from the IL-1 receptor (IL-1R)/Toll-like receptor (TLR) and TNF receptor (TNFR) superfamilies are critical for regulating the function of antigen-presenting cells. Signals transduced by these molecules lead to increased expression and activation of transcription factors such as NF-?B (1,2). TNF receptor-associated factor 6 (TRAF6) is unique in that it is a signaling adapter molecule common to both families (3). TRAF6 is important in cytokine production, dendritic cell (DC) maturation, and the T cell stimulatory capacity of DCs in response to TLR and CD40 ligands (4). It can be activated in the IL-1R/TLR signaling pathway by IL-1 receptor-associated kinase 1 (IRAK-1) (5) or by other TLR adaptor molecules such as TRIF (6). Also, it has been shown that TRAF6 can interact directly with TNFR family members CD40 and RANK (7).
Related PathwayDruggable Genome MAPK signaling pathwayUbiquitin mediated proteolysisEndocytosisToll-like receptor signaling pathwayNOD-like receptor signaling pathwayRIG-I-like receptor signaling pathwayMore Pathways >>

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
Western blot analysis of TRAF6 in PC-3 cell lysates with TRAF6 antibody at 1 ug/mL in the presence (A) or absence (B) of 1 ug blocking peptide.
IF Image
Immunocytochemistry of TRAF6 in K562 cells with TRAF6 antibody at 0.5 ug/mL.

 

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