Home Antibody All anti-AICDA antibodies
Also for AICDA (NM_020661)
|AID antibody was raised against a peptide corresponding to 14 amino acids near the carboxy-terminus of human AID.|
||0.5~1.0 mg/ml (Lot Dependent)
||ELISA, WB: 2 ug/ml, ICC: 10 ug/ml, IF: 20 ug/ml
|PBS containing 0.02% sodium azide.|
|Affinity chromatography purified via peptide column (Protein A or G Sepharose)
|Homo sapiens activation-induced cytidine deaminase (AICDA)|
|AID; ARP2; CDA2; HIGM2|
|Activation-induced cytidine deaminase (AID) was initially discovered as a homolog of the apolipoprotein B RNA-editing cytidine deaminase 1 (APOBEC1) that showed cytidine deaminase properties in stimulated B cell lines (1). It is necessary for somatic hypermutation and class switch recombination in B cells (2), but inappropriate or dysregulated expression AID is often found in tumors and B cell neoplasms (2,3). Although it is structurally and functionally similar to the APOBEC proteins (reviewed in 4), it appears unlikely that AID deaminates dC to dU residues in HIV cDNA as does APOBEC3G (5).|
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Western blot analysis of AID in Ramos whole cell lysate with AID antibody at 2 ug/mL in either the (A) absence or (B) presence of blocking peptide.
Immunocytochemistry of AID in Ramos cells with Ramos antibody at 10 ug/mL.