Home Antibody All anti-HTRA2 antibodies
Also for HTRA2 (NM_013247)
|OMI antibody was raised against a peptide corresponding to 16 amino acids near the C-terminus of human Omi.|
||WB: 0.5 - 1 ug/ml
|PBS containing 0.02% sodium azide.|
|Ion exchange chromatography purified
|Homo sapiens HtrA serine peptidase 2 (HTRA2), transcript variant 1|
|OMI; PARK13; PRSS25|
|Inhibitor of apoptosis proteins (IAPs) were initially identified in baculoviruses as proteins that inhibit apoptosis of the host cells to allow time for viral replication (1). Cellular homologues containing at least one baculoviral IAP repeat (BIR) motif essential for their anti-apoptosis activity have been identified in yeasts and higher organisms and often act by binding and inhibiting processed caspases (reviewed in 2). The activity of these proteins can be modulated by the expression of proteins such as Smac/DIABLO and XAF-1 which displace or prevent the binding of caspases by IAPs (reviewed in 3). Recently, a mitochondrial serine protease termed Omi/HtrA2 has been found to bind IAPs (4). Similar to Smac, Omi possesses a conserved IAP-binding motif, but acts to cleave IAPs to irreversibly inactivate IAPs and promote apoptosis (5).|
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Western blot analysis of OMI in U937 lysate with Omi antibody at (A) 0.5, (B) 1, and (C) 2 ug/ml.
Immunohistochemistry of OMI in human liver tissue with OMI antibody at 2 ug/ml.