Home Antibody All anti-BBC3 antibodies
Also for BBC3 (NM_001127240)
|PUMA antibody was raised against a synthetic peptide corresponding to 14 amino acids near the carboxy terminus of human PUMA-a (GenBank Accession number Q9BXH1) This sequence is identical between a and b forms of the PUMA proteins.|
||ELISA, WB: 2 ug/ml, ICC, IF: 1 ug/ml
|PBS containing 0.02% sodium azide.|
|Affinity chromatography purified via peptide column
|Homo sapiens BCL2 binding component 3 (BBC3), transcript variant 1|
|JFY-1; JFY1; PUMA|
Entrez Gene 27113 Human
Entrez Gene 170770 Mouse
|Apoptosis is related to many diseases and development. The p53 tumor-suppressor protein induces apoptosis through transcriptional activation of several genes. A novel p53 inducible pro-apoptotic gene was identified recently and designated PUMA (for p53 upregulated modulator of apoptosis) and bbc3 (for Bcl-2 binding component 3) in human and mouse (1-3). PUMA/bbc3 is one of the pro-apoptotic Bcl-2 family members including Bax and Noxa, which are also transcriptional targets of p53. The PUMA gene encodes two BH3 domain-containing proteins termed PUMA-alpha and PUMA-beta (1). PUMA proteins bind Bcl-2, localize to the mitochondria, and induce cytochrome c release and apoptosis in response to p53. PUMA may be a direct mediator of p53-induced apoptosis.|
|Druggable Genome p53 signaling pathwayHuntington's disease|
* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.
Western blot analysis of PUMA expression in human (H) K562 and mouse (M) 3T3 cell lysates with PUMA antibody at 2 ug/ml
Immunocytochemistry of PUMA in K562 cells with PUMA antibody at 1 ugg/mL.