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Home Antibody All anti-BBC3 antibodies

Anti-BBC3 Antibody

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA306108
  • Rabbit Polyclonal PUMA Antibody
  • Free Sample of Positive Control: HEK293T cell transient overexpression lysate (LC426734) , 20ug
100ug 325 3-7 Days
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WB(1)
IF(1)
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Also for BBC3 (NM_001127240)
cDNA Clone shRNA/siRNA Lysate Protein Antibody

OriGene Data

ImmunogenPUMA antibody was raised against a synthetic peptide corresponding to 14 amino acids near the carboxy terminus of human PUMA-a (GenBank Accession number Q9BXH1) This sequence is identical between a and b forms of the PUMA proteins.
Clone Name IsotypeIgG
Species ReactivityHuman, Mouse Concentration1ug/ul
Guaranteed Application *WB, IF Suggested DilutionsELISA, WB: 2 ug/ml, ICC, IF: 1 ug/ml
BufferPBS containing 0.02% sodium azide.
Purification Affinity chromatography purified via peptide column

Reference Data

Target NameHomo sapiens BCL2 binding component 3 (BBC3), transcript variant 1
Alternative NameJFY-1; JFY1; PUMA
Database LinkNP_001120712
FunctionApoptosis is related to many diseases and development. The p53 tumor-suppressor protein induces apoptosis through transcriptional activation of several genes. A novel p53 inducible pro-apoptotic gene was identified recently and designated PUMA (for p53 upregulated modulator of apoptosis) and bbc3 (for Bcl-2 binding component 3) in human and mouse (1-3). PUMA/bbc3 is one of the pro-apoptotic Bcl-2 family members including Bax and Noxa, which are also transcriptional targets of p53. The PUMA gene encodes two BH3 domain-containing proteins termed PUMA-alpha and PUMA-beta (1). PUMA proteins bind Bcl-2, localize to the mitochondria, and induce cytochrome c release and apoptosis in response to p53. PUMA may be a direct mediator of p53-induced apoptosis.
Related Pathway
Apoptosis

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
Western blot analysis of PUMA expression in human (H) K562 and mouse (M) 3T3 cell lysates with PUMA antibody at 2 ug/ml
IF Image
Immunocytochemistry of PUMA in K562 cells with PUMA antibody at 1 ugg/mL.

 

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