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Home Antibody All anti-AATF antibodies

Anti-AATF Antibody

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA306107
  • Rabbit Polyclonal AATF Antibody
  • Free Sample of Positive Control: HEK293T cell transient overexpression lysate (LC415905) , 20ug Explanation
100ug 325 3-7 Days
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WB(1)
IHC(1)

OriGene Data

ImmunogenAATF antibody was raised against a 12 amino acid peptide from near the carboxy terminus of human AATF.
Clone Name IsotypeIgG
Species ReactivityHuman, Mouse Concentration1ug/ul
Guaranteed Application *WB, IHC Suggested DilutionsWB: 0.5 - 1 ug/ml; IHC: 10ug/ml
BufferPBS containing 0.02% sodium azide.
Purification Immunoaffinity purified IgG

Reference Data

Target NameHomo sapiens apoptosis antagonizing transcription factor (AATF)
Alternative NameBFR2; CHE-1; CHE1; DED
Database LinkNP_036270
Entrez Gene 26574 Human
Entrez Gene 56321 Mouse
FunctionAATF (apoptosis antagonizing transcription factor) was initially discovered as an interaction partner of ZIP kinase (ZIPK) (1), a member of death-associated protein (DAP) kinase family of pro-apoptotic serine/threonine kinases (2). AATF is a phosphoprotein containing an acidic region and a putative leucine zipper domain and nuclear localization signal, features which are typical of transcription factors. AATF inhibits the ZIPK-mediated pro-apoptotic pathway and may activate other anti-apoptotic pathways (3). Recently, it has also been shown to protect neural cells against oxidative damage induced by amyloid b-peptide and to inhibit aberrant production of the b-peptide by interacting with Par-4 (prostate apoptosis response-4), another pro-apoptotic leucine zipper protein that is associated with neuronal degeneration in Alzheimer’s disease (AD) (4,5), suggesting that AATF may have potential therapeutic applications in both familial and sporadic forms of AD.
Related Pathway

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
Western blot analysis of AATF in human small intestine cell lysate with AATF antibody at (A) 0.5, (B) 1 and (C) 2 ug/ml.
IHC Image
Immunohistochemistry of AATF in human small intestine tissue with AATF antibody at 10 ug/ml.

 

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