Home Antibody All anti-BCL2L13 antibodies
Also for BCL2L13 (NM_015367)
|Bcl-rambo antibody was raised against a 15 amino acid peptide from near the center of human Bcl-rambo.|
|Human, Mouse, Rat
||WB: 2 ug/ml
|PBS containing 0.02% sodium azide.|
|Affinity chromatography purified via peptide column
|Homo sapiens BCL2-like 13 (apoptosis facilitator) (BCL2L13), transcript variant 1|
|BCL-RAMBO; Bcl2-L-13; MIL1|
Entrez Gene 23786 Human
Entrez Gene 94044 Mouse
Entrez Gene 312682 Rat
|Apoptosis plays a major role in normal organism development, tissue homeostasis, and removal of damaged cells. Disruption of this process has been implicated in a variety of diseases such as cancer (reviewed in 1). Members of the Bcl-2 family are known to be critical regulators of this process. These proteins are characterized by the presence of several conserved motifs termed Bcl-2 homology (BH) domains (reviewed in 2 and 3). A novel, widely expressed member termed Bcl-rambo was recently identified. This protein is localized to mitochondria in mammalian cells and its overexpression induces apoptosis which could be blocked by co-expression of inhibitor of apoptosis proteins (IAPs) such as XIAP, cIAP1, and cIAP2 (4). Bcl-rambo shows overall homology to the anti-apoptotic members containing BH motifs, but unlike Bcl-2, the C-terminal membrane anchor of Bcl-rambo is preceded by a unique 250 amino acid insertion. This region by itself can induce apoptosis more efficiently than the Bcl-2 homology regions, suggesting that Bcl-rambo may be important other pro-apoptotic pathways (4).|
|TransmembraneDruggable Genome |
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Western blot analysis of Bcl-rambo in K562 cell lysate with Bcl-rambo antibody at (A) 2 and (B) 4 ug/ml.
Immunohistochemistry of Bcl-rambo in human heart tissue with Bcl-rambo antibody at 10 ug/ml.