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Home Antibody All anti-BCL2L13 antibodies

Anti-BCL2L13 Antibody

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA306100
  • Rabbit Polyclonal Bcl-rambo Antibody
  • Free Sample of Positive Control: HEK293T cell transient overexpression lysate (LC414596) , 20ug
100ug 325 3-7 Days
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WB(1)
IHC(1)
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Also for BCL2L13 (NM_015367)
cDNA Clone shRNA/siRNA Lysate Protein Antibody

OriGene Data

ImmunogenBcl-rambo antibody was raised against a 15 amino acid peptide from near the center of human Bcl-rambo.
Clone Name IsotypeIgG
Species ReactivityHuman, Mouse, Rat Concentration1ug/ul
Guaranteed Application *WB, IHC Suggested DilutionsWB: 2 ug/ml
BufferPBS containing 0.02% sodium azide.
Purification Affinity chromatography purified via peptide column

Reference Data

Target NameHomo sapiens BCL2-like 13 (apoptosis facilitator) (BCL2L13), transcript variant 1
Alternative NameBCL-RAMBO; Bcl2-L-13; MIL1
Database LinkNP_056182
FunctionApoptosis plays a major role in normal organism development, tissue homeostasis, and removal of damaged cells. Disruption of this process has been implicated in a variety of diseases such as cancer (reviewed in 1). Members of the Bcl-2 family are known to be critical regulators of this process. These proteins are characterized by the presence of several conserved motifs termed Bcl-2 homology (BH) domains (reviewed in 2 and 3). A novel, widely expressed member termed Bcl-rambo was recently identified. This protein is localized to mitochondria in mammalian cells and its overexpression induces apoptosis which could be blocked by co-expression of inhibitor of apoptosis proteins (IAPs) such as XIAP, cIAP1, and cIAP2 (4). Bcl-rambo shows overall homology to the anti-apoptotic members containing BH motifs, but unlike Bcl-2, the C-terminal membrane anchor of Bcl-rambo is preceded by a unique 250 amino acid insertion. This region by itself can induce apoptosis more efficiently than the Bcl-2 homology regions, suggesting that Bcl-rambo may be important other pro-apoptotic pathways (4).
Related Pathway

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
Western blot analysis of Bcl-rambo in K562 cell lysate with Bcl-rambo antibody at (A) 2 and (B) 4 ug/ml.
IHC Image
Immunohistochemistry of Bcl-rambo in human heart tissue with Bcl-rambo antibody at 10 ug/ml.

 

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