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Home Antibody All anti-NDEL1 antibodies

Anti-NDEL1 Antibody

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA306096
  • Rabbit Polyclonal Nudel Antibody
  • Free Sample of Positive Control: HEK293T cell transient overexpression lysate (LC422448) , 20ug
100ug 325 3-7 Days
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WB(1)
IF(1)
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Also for NDEL1 (NM_001025579)
cDNA Clone shRNA/siRNA Lysate Protein Antibody

OriGene Data

ImmunogenNudel antibody was raised against a peptide corresponding to 15 amino acids near the amino terminus of human Nudel.
Clone Name IsotypeIgG
Species ReactivityHuman, Mouse Concentration1ug/ul
Guaranteed Application *WB, IF Suggested DilutionsELISA, WB: 0.5 - 2 ug/ml, ICC: 2 ug/ml, IF: 10 ug/ml
BufferPBS containing 0.02% sodium azide.
Purification Affinity chromatography purified via peptide column

Reference Data

Target NameHomo sapiens nudE neurodevelopment protein 1-like 1 (NDEL1), transcript variant 1
Alternative NameEOPA; MITAP1; NDE1L1; NDE2; NUDEL
Database LinkNP_001020750
FunctionNudel was initially discovered as a protein homologous to Aspergillus NUDE and that associated with Lis1 and polyprotein complex cytoplasmic dynein, both of which have been linked to neuronal development and migration (1,2). It was later shown to be a substrate of cdk5, a kinase known to be critical during neuronal migration; phosphorylation of Nudel by cdk5 affects its localization in neurons and affects neuritic morphology (1,3). It is thought that together with Lis1, Nudel regulates cytoplasmic dynein, a large polyprotein complex, in neuronal migration and mitosis through direct interactions (4). Similar interactions are thought to also play a role in membrane traffic in other cells as disruption of Nudel expression through RNA interference perturbed normal endomembrane flux and resulted in the fragmentation of the Golgi apparatus (3).
Related Pathway
Cell cycle

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WB Image
Western blot analysis of Nudel in Jurkat whole cell lysate with Nudel antibody at (A) 0.5, (B) 1, or (C) 2 ug/mL.
IF Image
Immunocytochemistry of Nudel in Jurkat cells with Nudel antibody at 2 ug/mL.

 

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