Home Antibody All anti-NDEL1 antibodies
Also for NDEL1 (NM_001025579)
|Nudel antibody was raised against a peptide corresponding to 15 amino acids near the amino terminus of human Nudel.|
||ELISA, WB: 0.5 - 2 ug/ml, ICC: 2 ug/ml, IF: 10 ug/ml
|PBS containing 0.02% sodium azide.|
|Affinity chromatography purified via peptide column (Protein A or G Sepharose)
|Homo sapiens nudE neurodevelopment protein 1-like 1 (NDEL1), transcript variant 1|
|EOPA; MITAP1; NDE1L1; NDE2; NUDEL|
|Nudel was initially discovered as a protein homologous to Aspergillus NUDE and that associated with Lis1 and polyprotein complex cytoplasmic dynein, both of which have been linked to neuronal development and migration (1,2). It was later shown to be a substrate of cdk5, a kinase known to be critical during neuronal migration; phosphorylation of Nudel by cdk5 affects its localization in neurons and affects neuritic morphology (1,3). It is thought that together with Lis1, Nudel regulates cytoplasmic dynein, a large polyprotein complex, in neuronal migration and mitosis through direct interactions (4). Similar interactions are thought to also play a role in membrane traffic in other cells as disruption of Nudel expression through RNA interference perturbed normal endomembrane flux and resulted in the fragmentation of the Golgi apparatus (3).|
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Western blot analysis of Nudel in Jurkat whole cell lysate with Nudel antibody at (A) 0.5, (B) 1, or (C) 2 ug/mL.
Immunocytochemistry of Nudel in Jurkat cells with Nudel antibody at 2 ug/mL.