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Home Antibody All anti-LRRC1 antibodies

Anti-LRRC1 Antibody

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA306094
  • Rabbit Polyclonal Lano Antibody
  • Free Sample of Positive Control: HEK293T cell transient overexpression lysate (LC413222) , 20ug Explanation
100ug 325 3-7 Days
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WB(1)
IHC(1)
IF(1)

OriGene Data

ImmunogenLano antibody was raised against a peptide corresponding to 15 amino acids near the carboxy terminus of human Lano.
Clone Name IsotypeIgG
Species ReactivityHuman Concentration1ug/ul
Guaranteed Application *WB, IHC, IF Suggested DilutionsWB: 1 - 2 ug/ml, IHC: 10 ug/ml, IF: 20 ug/ml
BufferPBS containing 0.02% sodium azide.
Purification Affinity chromatography purified via peptide column

Reference Data

Target NameHomo sapiens leucine rich repeat containing 1 (LRRC1)
Alternative NamedJ523E19.1; LANO
Database LinkNP_060684
Entrez Gene 55227 Human
FunctionLano is a member of the LAP (leucine-rich repeats and PDZ) family of proteins that also includes Densin-180, Erbin, and hScribble (1). The LAP proteins generally contain multiple leucine-rich repeat (LRR) domains which serve to target them to the basolateral membrane of epithelial cells (2). Lano is unique in that it alone does not possess one or more PDZ (PSD95/DLG/ZO-1) domains as do the other members of the LAP family. However, it can bind to the PDZ domain of Erbin in addition to those of membrane-associated and guanylate kinase (MAGUK) proteins which regulate adhesion and plasticity at cell junctions (1,3). It has been suggested that it is through these interaction that these LAP proteins participate in the maintenance of proper embryonic development and integrity of epithelial tissues (4,5).
Related Pathway

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
Western blot analysis of Lano in PC-3 whole cell lysate with Lano antibody at (A) 1 or (B) 2 ug /ml.
IHC Image
Immunohistochemistry of Lano in human colon tissue with Lano antibody at 10 ug/ml.
IF Image
Immunofluorescence of Lano in human colon tissue with Lano antibody at 20 ug/mL.

 

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