Home Antibody All anti-NOD2 antibodies
Also for NOD2 (NM_022162)
|Rabbit NOD2 polyclonal antibody was raised against a synthetic peptide corresponding to 14 amino acids at the carboxy terminus of human NOD2.|
||ELISA, WB: 2 - 4 ug/ml, ICC: 10 ug/ml, IF: 20 ug/ml
|PBS containing 0.02% sodium azide.|
|Immunoaffinity chromatography purified IgG
|Homo sapiens nucleotide-binding oligomerization domain containing 2 (NOD2), transcript variant 1|
|ACUG; BLAU; CARD15; CD; CLR16.3; IBD1; NLRC2; NOD2B; PSORAS1|
Entrez Gene 64127 Human
|Apaf-1 and NOD1 are members of a new family (1), which are involved in the regulation of apoptosis and immune response. Each of them contains a caspase recruitment domain (CARD) and a nucleotide-binding oligomerization domain (NOD). A third member in this family was recently identified and designated NOD2 (2). NOD2 interacts with RICK via a homophilic CARD-CARD interaction. NOD2 activates NF-kappaB, which is regulated by its carboxy-terminal leucine-rich repeat domain that acts as an intracellular receptor for components of bacteria. The variants of NOD2, either a frameshift or a missense, were associated with Crohn’s disease (3,4) that is a main type of chronic inflammatory bowel disease.|
|Druggable Genome NOD-like receptor signaling pathway|
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Western blot analysis of NOD2 in HeLa cell lysate with NOD2 antibody at (A) 2 and (B) 4 ug/mL.
Immunocytochemistry of NOD2 in HeLa cells with NOD2 antibody at 10 ug/mL.