Home Antibody All anti-NKIRAS2 antibodies
Also for NKIRAS2 (NM_001001349)
|KappaB ras2 antibody was raised against a 14 amino acid peptide from near the carboxy terminus of human KappaB ras2.|
|Human, Mouse, Rat
||WB: 0.5 - 1 ug/ml
|PBS containing 0.02% sodium azide.|
|Affinity chromatography purified via peptide column
|Homo sapiens NFKB inhibitor interacting Ras-like 2 (NKIRAS2), transcript variant 1|
|KappaB ras-1 (kappaB-ras-1) and kappaB-ras-2 are two small proteins that similar to Ras-like small GTPases that associate with IkappaB (IkappaB), an inhibitor of the transcription factor NF-kappaB. IkappaB exists in two homologous forms, IkappaB-alpha and IkappaB-beta, although IkappaB-beta contains a unique 47-amino acid region within its ankyrin domain. While inactive IkappaB-alpha-NF-kappaB complexes can shuttle in and out of the nucleus, IkappaB-beta-NF-kappaB complexes are retained exclusively in the cytoplasm. It is suggested that kappaB-ras proteins preferentially bind to the IkappaB-beta form through this unique insert within the ankyrin region, thus modulating the cellular location of IkappaB-beta and regulating the rate of degradation of IkappaB-beta. This antibody is specific for kappaB-ras2 and has no cross-reactivity to kappaB-ras1.|
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Western blot analysis of KappaB ras2 in RAW264.7 cell lysate with KappaB ras1 antibody at 1 µg/ml in the (A) absence and (B) presence of blocking peptide.