Home Antibody All anti-IL21R antibodies
Also for IL21R (NM_021798)
|IL-21 receptor antibody was raised against a synthetic peptide corresponding to amino acids 20 to 32 of human IL-21 receptor precursor.|
|Human, Mouse, Rat
||WB: 0.5 - 1 ug/ml
|PBS containing 0.02% sodium azide.|
|Affinity chromatography purified via peptide column (Protein A or G Sepharose)
|Homo sapiens interleukin 21 receptor (IL21R), transcript variant 1|
|A novel cytokine related to IL2 and IL15 was recently identified and designated IL-21 . The receptor for IL-21 (IL-21R, also termed NILR for novel Interleukin receptor) is a new member of the class I cytokine receptor family (1,2). IL-21R forms a complex with the common cytokine receptor g chain, gc, and mediates IL-21 signaling (3,4). Both IL-21R and the gc are necessary for the IL-21 function. IL-21 and its receptor activate JAK-STAT signaling pathway. IL-21R is expressed in spleen, thymus, natural killer (NK), T and B cell lines. IL-21 plays a role in the proliferation and maturation of NK, B and T cell populations.|
Cytokine-cytokine receptor interaction
Jak-STAT signaling pathway
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Western blot analysis of IL-21 receptor expression in human Raji cell lysate with IL-21 receptor antibody at 1 µg /ml.