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Home Antibody All anti-AVEN antibodies

Anti-AVEN Antibody


Specifications Citations Customer Reviews Product Documents
SKU Description Amount Price Availability*  
TA306068 Rabbit Polyclonal Aven Antibody 100ug $325 3-7 Days
LC412513 AVEN HEK293T cell transient overexpression lysate (as WB positive control) 20ug $50 In Stock
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OriGene Data

ImmunogenAven antibody was raised against a 14 amino acid peptide from near the carboxy terminus of human Aven.
Clone Name IsotypeIgG
Species ReactivityHuman, Mouse, Rat Concentration1ug/ul
Guaranteed Application *WB, IHC Suggested DilutionsWB: 0.5 - 1 ug/ml
BufferPBS containing 0.02% sodium azide.
Purification Affinity chromatography purified via peptide column

Reference Data

Target NameHomo sapiens apoptosis, caspase activation inhibitor (AVEN)
Alternative NamePDCD12
Database LinkNP_065104
Entrez Gene 57099 Human
Entrez Gene 74268 Mouse
Entrez Gene 311299 Rat
FunctionApoptosis plays a major role in normal organism development, tissue homeostasis, and removal of damaged cells. Disruption of this process has been implicated in a variety of diseases such as cancer. Aven is a recently discovered protein that blocks apoptosis induced by Apaf-1 and caspase-9. It is thought that Aven functions by binding to Bcl-xL, an antiapoptotic member of the Bcl-2 family, and to Apaf-1, possibly interfering with the ability of Apaf-1 to self-associate, suggesting that Aven impedes Apaf-1-mediated caspase activation. Higher levels of Aven mRNA are seen in patients with acute leukemia than in control patients, suggesting that Aven may be useful as a prognostic indicator in leukemia patients. Despite its predicted molecular weight, Aven often migrates at 55 kDa in SDS-PAGE.
Related Pathway

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

Western blot analysis of Aven in Raji cell lysate with Aven antibody at 1 ug/ml in (A) the presence and (B) the absence of blocking peptide.
Immunohistochemistry of Aven in human spleen tissue with Aven antibody at 5 ug/ml.


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