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Home Antibody All anti-Diablo antibodies

Anti-Diablo Antibody

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA306067
  • Rabbit Polyclonal Smac Antibody
  • FREE positive control: HEK293T cell transient overexpression lysate (LC429603) , 20ug
100ug 325 3-7 Days
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WB(1)
IHC(1)
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Also for Diablo (NM_019887)
cDNA Clone shRNA/siRNA Lysate Protein Request Antibody

OriGene Data

ImmunogenSmac antibody was raised against a peptide corresponding to amino acids 222 to 237 of murine Smac/DIABLO.
Clone Name IsotypeIgG
Species ReactivityHuman, Mouse, Rat Concentration1ug/ul
Guaranteed Application *WB, IHC Suggested DilutionsWB: 0.5 - 1 ug/ml
BufferPBS containing 0.02% sodium azide.
Purification Affinity chromatography purified via peptide column

Reference Data

Target NameHomo sapiens diablo, IAP-binding mitochondrial protein (DIABLO), transcript variant 1
Alternative NameDFNA64; SMAC
Database LinkNP_063940
FunctionThe inhibitor of apoptosis proteins (IAPs) regulate programmed cell death by inhibiting members of the caspase family of enzymes. A novel mammalian protein that binds to IAPs and neutralizes the inhibitory effect of IAPs on caspases was recently identified and designated Smac/DIABLO (1,2). Smac/DIABLO is a mitochondrial protein that is released along with cytochrome c during apoptosis and activates cytochrome c/Apaf-1/capase-9 pathway. Analysis of the structural basis of Smac/DIABLO reveals that the N-terminal amino acids are required for binding of Smac/DIABLO to IAPs and activation of caspases (3-6). Smac/DIABLO is expressed in a variety of human and mouse tissues (1,2).
Related Pathway
Apoptosis

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WB Image
Western blot analysis of Smac in mouse heart tissue lysate in the absence (A) or presence (B) of blocking peptide and in rat heart tissue lysate with Smac antibody at 1 ug /ml.
IHC Image
Immunohistochemical staining of mouse spleen tissue using mSmac antibody at 2 ug/ml.

 

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