Home Antibody All anti-RRM2B antibodies
Also for RRM2B (NM_001172477)
|p53R2 antibody was raised against a synthetic peptide corresponding to amino acids 2 to 17 of human p53R2 .|
|Human, Mouse, Rat
||WB: 0.5 - 1 ug/ml
|PBS containing 0.02% sodium azide.|
|Affinity chromatography purified via peptide column
|Homo sapiens ribonucleotide reductase M2 B (TP53 inducible) (RRM2B), transcript variant 2|
|MTDPS8A; MTDPS8B; P53R2|
Entrez Gene 50484 Human
Entrez Gene 382985 Mouse
Entrez Gene 299976 Rat
|The p53 tumor-suppresspr gene integrates numerous signals that control cell life and death. Several novel molecules involved in p53 signaling, including p53R2 , Chk2 (2), p53AIP1 (3), Noxa (4), PIDD (5), and PID/MTA2 (6), were recently discovered. p53R2 is a p53 inducible gene that contains a p53 binding sequence and encodes a subunit of the enzyme ribonucleotide reductase (1,7). p53R2 is induced by the reagents, ultraviolet and g-irradiation that cause DNA damages. The product of p53R2 gene is directly involved in the p53 checkpoint for repair of damaged DNA. The isoform of the p53 family member p73 also induces p53R2 expression (8). p53R2 is an important target of p53 for tumour suppression.|
|TransmembraneDruggable Genome Purine metabolismPyrimidine metabolismGlutathione metabolismMetabolic pathwaysp53 signaling pathway|
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Western blot analysis of p53R2 expression in A431 cell lysate at (A) 0.5 and (B) 1 ug /ml.
Immunohistochemistry of p53R2 in human lung tissue with p53R2 antibody at 1 ug/ml.