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Home Antibody All anti-RRM2B antibodies

Anti-RRM2B Antibody


Specifications Citations Customer Reviews Product Documents
SKU Description Amount Price Availability*  
TA306062 Rabbit Polyclonal p53R2 Antibody 100ug $325 3-7 Days
LC433055 RRM2B HEK293T cell transient overexpression lysate (as WB positive control) 20ug $50 In Stock
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OriGene Data

Immunogenp53R2 antibody was raised against a synthetic peptide corresponding to amino acids 2 to 17 of human p53R2 .
Clone Name IsotypeIgG
Species ReactivityHuman, Mouse, Rat Concentration1ug/ul
Guaranteed Application *WB, IHC, IF Suggested DilutionsWB: 0.5 - 1 ug/mL, ICC: 1 ug/mL, IF: 20 ug/mL
BufferPBS containing 0.02% sodium azide.
Purification Affinity chromatography purified via peptide column

Reference Data

Target NameHomo sapiens ribonucleotide reductase regulatory TP53 inducible subunit M2B (RRM2B), transcript variant 2
Alternative NameMTDPS8A; MTDPS8B; P53R2
Database LinkNP_001165948
Entrez Gene 50484 Human
Entrez Gene 382985 Mouse
Entrez Gene 299976 Rat
FunctionThe p53 tumor-suppresspr gene integrates numerous signals that control cell life and death. Several novel molecules involved in p53 signaling, including p53R2 , Chk2 (2), p53AIP1 (3), Noxa (4), PIDD (5), and PID/MTA2 (6), were recently discovered. p53R2 is a p53 inducible gene that contains a p53 binding sequence and encodes a subunit of the enzyme ribonucleotide reductase (1,7). p53R2 is induced by the reagents, ultraviolet and g-irradiation that cause DNA damages. The product of p53R2 gene is directly involved in the p53 checkpoint for repair of damaged DNA. The isoform of the p53 family member p73 also induces p53R2 expression (8). p53R2 is an important target of p53 for tumour suppression.
Related PathwayTransmembraneDruggable Genome Purine metabolismPyrimidine metabolismGlutathione metabolismMetabolic pathwaysp53 signaling pathway

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
Western blot analysis of p53R2 expression in A431 cell lysate at (A) 0.5 and (B) 1 ug /ml.

IHC Image
Immunohistochemistry of p53R2 in human lung tissue with p53R2 antibody at 1 ug/ml.

IF Image
Immunofluorescence of p53R2 in Human Lung tissue with p53R2 antibody at 20 ug/mL.


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